Stable black phosphorus/Bi2O3 heterostructures for synergistic cancer radiotherapy

	Stable black phosphorus/Bi2O3 heterostructures for synergistic cancer radiotherapy
	Paul K. Chu; Xue-Feng Yu; Tianfeng Chen; Jie Gao; Na Yang; Jiahong Wang; Guangbo Qu; Wenhua Zhou; Lizhen He; Hao Huang
刊名	Biomaterials
	2018
文献子类	期刊论文
英文摘要	X-ray induced photodynamic therapy (X-ray-PDT) is a promising approach for synergistic cancer radiotherapy and development of suitable radiosensitizers is highly desired. In this paper, we propose black phosphorus/Bi2O3 (BP/Bi2O3) heterostructures as efficient and biocompatible radiosensitizers for synergistic cancer radiotherapy. The heterostructures are synthesized by growth of ultrasmall Bi2O3 nanoparticles onto BP nanosheets. The Bi2O3 decoration inhibits the rapid degradation of BP nanosheets by occupation of the defect sites, and the synergistic effects of BP and Bi2O3 enable 1O2 overproduction under X-ray irradiation. This X-ray-PDT effect of the BP/Bi2O3 nanosheets enhances the radiotherapy activity towards cancer cells by inducing cell apoptosis and cycle arrest. In vivo treatment of melanoma conducted on a clinical radiotherapeutic instrument demonstrates that the BP/Bi2O3 sensitized radiotherapy inhibits tumor growth efficiently. Furthermore, the BP/Bi2O3 nanosheets composed of biological friendly P, O, and Bi elements shows good biocompatibility in vitro and in vivo. This radiosensitizer thus has immense clinical potential for cancer therapy, and our findings reveal a general strategy to fabricate stable BP-based heterostructures for different applications.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/14656]
专题	深圳先进技术研究院_医药所
推荐引用方式 GB/T 7714	Paul K. Chu,Xue-Feng Yu,Tianfeng Chen,et al. Stable black phosphorus/Bi2O3 heterostructures for synergistic cancer radiotherapy[J]. Biomaterials,2018.
APA	Paul K. Chu.,Xue-Feng Yu.,Tianfeng Chen.,Jie Gao.,Na Yang.,...&Hao Huang.(2018).Stable black phosphorus/Bi2O3 heterostructures for synergistic cancer radiotherapy.Biomaterials.
MLA	Paul K. Chu,et al."Stable black phosphorus/Bi2O3 heterostructures for synergistic cancer radiotherapy".Biomaterials (2018).