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	Biphasic Biodegradeble Osteochondral Scaffold
	Mauro Alini; Xinluan Wang; Xiangbo Meng; Long Li; Yuxiao Lai; Sibylle Grad; Ling Qin
	2018
会议日期	2018
会议地点	Kyoto
英文摘要	Three dimensional (3D) scaffolds have many advantageous properties for osteochondral repair, due to its controllable properties such as pore size, porosity and morphology. In this study, biphasic bioactive biodegradable scaffolds have been developed by low temperature 3D printing technology, the upper layer of which is composed of poly lactic-co-glycolic acid (PLGA) for cartilage repair, and the lower one is the composite of poly lactic-co-glycolic acid and tricalcium phosphate (P-T) for subchondral bone repair. The morphologies and porosity of the biphasic scaffolds were observed by scanning electron microscopy (SEM) and micro-CT, respectively. The mechanical properties were tested on an electronic universal mechanical tester. Micro CT data showed that the porosities of PLGA and PT layer were 43% and 48%, respectively. The pore sizes of the macro-pores in PLGA and PT layer were 420-480 μm and 450-550 μm, respectively. SEM images demonstrated the micropores were about 5-50 μm, as well as the clear boundary between two layers. Mechanical test results showed that the compressive modulus and compressive strength of the PLGA layer were 13.35 MPa and 704.1KPa, and that of the PT layer were 23.71 MPa and 1.173MPa, respectively. Our results demonstrated a bi-layer scaffold was well fabricated with proper porosity and pore size for osteochondral regeneration. The degradation properties are on going and we also try to use it as a delivery system carrying bioactive factors to promote bone and cartilage regeneration. Acknowledgements: This work was supported by Sino-Swiss collaborative project from Ministry of Science and Technology (2015DFG32200) and the Swiss National Science Foundation under the SSSTC program (156362).
URL标识	查看原文
内容类型	会议论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/14582]
专题	深圳先进技术研究院_医工所
推荐引用方式 GB/T 7714	Mauro Alini,Xinluan Wang,Xiangbo Meng,et al. Biphasic Biodegradeble Osteochondral Scaffold[C]. 见:. Kyoto. 2018.

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