PIEZO channel protein naturally expressed in human breast cancer cell MDA-MB-231 as probed by atomic force microscopy

	PIEZO channel protein naturally expressed in human breast cancer cell MDA-MB-231 as probed by atomic force microscopy
	Jiangyu Li; Hairong Zheng; Yuanqi Weng; Fei Yan; Runkang Chen; Ming Qian; Yun Ou; Shuhong Xie
刊名	AIP ADVANCES
	2018
文献子类	期刊论文
英文摘要	Mechanical stimuli drives many physiological processes through mechanically activated channels, and the recent discovery of PIEZO channel has generated great interests in its mechanotransduction. Many previous researches investigated PIEZO proteins by transcribing them in cells that originally have no response to mechanical stimulation, or by forming PIEZO-combined complexes in vitro, and few studied PIEZO protein’s natural characteristics in cells. In this study we show that MDA-MB-231, a malignant cell in human breast cancer cell line, expresses the mechanosensitive behavior of PIEZO in nature without extra treatment, and we report its characteristics in response to localized mechanical stimulation under an atomic force microscope, wherein a correlation between the force magnitude applied and the channel opening probability is observed. The results on PIEZO of MDA-MB- 231 can help establish a basis of preventing and controlling of human breast cancer cell via mechanical forces.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/14389]
专题	深圳先进技术研究院_医工所
推荐引用方式 GB/T 7714	Jiangyu Li,Hairong Zheng,Yuanqi Weng,et al. PIEZO channel protein naturally expressed in human breast cancer cell MDA-MB-231 as probed by atomic force microscopy[J]. AIP ADVANCES,2018.
APA	Jiangyu Li.,Hairong Zheng.,Yuanqi Weng.,Fei Yan.,Runkang Chen.,...&Shuhong Xie.(2018).PIEZO channel protein naturally expressed in human breast cancer cell MDA-MB-231 as probed by atomic force microscopy.AIP ADVANCES.
MLA	Jiangyu Li,et al."PIEZO channel protein naturally expressed in human breast cancer cell MDA-MB-231 as probed by atomic force microscopy".AIP ADVANCES (2018).