GeneFuse: detection and visualization of target gene fusions from DNA sequencing data

	GeneFuse: detection and visualization of target gene fusions from DNA sequencing data
	Jia Gu; Shifu Chen; Ming Liu; Tanxiao Huang; Wenting Liao; Mingyan Xu
刊名	International Journal of Biological Sciences
	2018
文献子类	期刊论文
英文摘要	In recent years, gene fusion detection for cancer treatment has become increasingly important since more therapeutic agents have been developed to suppress fusion kinases. Although a number of tools have been developed to detect gene fusions from DNA sequencing data, most of them are not sensitive enough for processing the data from the samples with low tumor DNA composition, like cell-free tumor DNA. In this paper, we will introduce GeneFuse, a tool to detect and visualize gene fusions with high sensitivity and specificity. GeneFuse focuses on the curated gene fusions, which are available in COSMIC (the Catalogue of Somatic Mutations in Cancer) database. For each detected fusion, GeneFuse reports its genome locus, inferred protein forms, and supporting sequencing reads. The fusion detection results are visualized in an HTML page for cloud-friendly validation. GeneFuse is an open source tool available at GitHub: https://github.com/OpenGene/GeneFuse
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/14241]
专题	深圳先进技术研究院_医工所
推荐引用方式 GB/T 7714	Jia Gu,Shifu Chen,Ming Liu,et al. GeneFuse: detection and visualization of target gene fusions from DNA sequencing data[J]. International Journal of Biological Sciences,2018.
APA	Jia Gu,Shifu Chen,Ming Liu,Tanxiao Huang,Wenting Liao,&Mingyan Xu.(2018).GeneFuse: detection and visualization of target gene fusions from DNA sequencing data.International Journal of Biological Sciences.
MLA	Jia Gu,et al."GeneFuse: detection and visualization of target gene fusions from DNA sequencing data".International Journal of Biological Sciences (2018).