Facilitating Translational Nanomedicine via Predictive Safety Assessment

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境纳米材料实验室

	Facilitating Translational Nanomedicine via Predictive Safety Assessment
	Mirshafiee, Vahid; Jiang, Wen; Sun, Bingbing; Wang, Xiang; Xia, Tian
刊名	MOLECULAR THERAPY
	2017-07-05
卷号	25 期号:7 页码:1522-1530
英文摘要	Extensive research on engineered nanomaterials (ENMs) has led to the development of numerous nano-based formulations for theranostic purposes. Although some nano-based drug delivery systems already exist on the market, growing numbers of newly designed ENMs exhibit improved physicochemical properties and are being assessed in preclinical stages. While these ENMs are designed to improve the efficacy of current nano based therapeutic or imaging systems, it is necessary to thoroughly determine their safety profiles for successful clinical applications. As such, our aim in this mini-review is to discuss the current knowledge on predictive safety and structure-activity relationship (SAR) analysis of major ENMs at the developing stage, as well as the necessity of additional long-term toxicological analysis that would help to facilitate their transition into clinical practices. We focus on how the interaction of these nanomaterials with cells would trigger signaling pathways as molecular initiating events that lead to adverse outcomes. These mechanistic understandings would help to design safer ENMs with improved therapeutic efficacy in clinical settings.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/39466]
专题	生态环境研究中心_环境纳米材料实验室
推荐引用方式 GB/T 7714	Mirshafiee, Vahid,Jiang, Wen,Sun, Bingbing,et al. Facilitating Translational Nanomedicine via Predictive Safety Assessment[J]. MOLECULAR THERAPY,2017,25(7):1522-1530.
APA	Mirshafiee, Vahid,Jiang, Wen,Sun, Bingbing,Wang, Xiang,&Xia, Tian.(2017).Facilitating Translational Nanomedicine via Predictive Safety Assessment.MOLECULAR THERAPY,25(7),1522-1530.
MLA	Mirshafiee, Vahid,et al."Facilitating Translational Nanomedicine via Predictive Safety Assessment".MOLECULAR THERAPY 25.7(2017):1522-1530.