Phenolic compounds from the leaf extract of artichoke (Cynara scolymus L.) and their antimicrobial activities

doi:10.1021/jf0490192

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 中国科学院环境生物技术重点实验室

	Phenolic compounds from the leaf extract of artichoke (Cynara scolymus L.) and their antimicrobial activities
	Zhu, XF; Zhang, HX; Lo, R
刊名	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
	2004
卷号	52 期号:24 页码:7272-7278
关键词	Artichoke Cynara ScoL.mus L. Antimicrobial Activity Phenolic Compounds Caffeoylquinic Acid Derivatives Flavonoids
DOI	10.1021/jf0490192
英文摘要	A preliminary antimicrobial disk assay of chloroform, ethyl acetate, and n-butanol extracts of artichoke (Cynara scolymus L.) leaf extracts showed that the n-butanol fraction exhibited the most significant antimicrobial activities against seven bacteria species, four yeasts, and four molds. Eight phenolic compounds were isolated from the n-butanol soluble fraction of artichoke leaf extracts. On the basis of high-performance liquid chromatography/electrospray ionization mass spectrometry, tandem mass spectrometry, and nuclear magnetic resonance techniques, the structures of the isolated compounds were determined as the four caffeoylquinic acid derivatives, chlorogenic acid (1), cynarin (2), 3,5-di-O-caffeoylquinic acid (3), and 4,5-di-acaffeoylquinic acid (4), and the four flavonoids, luteolin-7-rutinoside (5), cynaroside (6), apigenin-7-rutinoside (7), and apigenin-7-O-beta-D-glucopyranoside (8), respectively. The isolated compounds were examined for their antimicrobial activities on the above microorganisms, indicating that all eight phenolic compounds showed activity against most of the tested organisms. Among them, chlorogenic acid, cynarin, luteolin-7-rutinoside, and cynaroside exhibited a relatively higher activity than other compounds; in addition, they were more effective against fungi than bacteria. The minimum inhibitory concentrations of these compounds were between 50 and 200 mug/mL.
WOS研究方向	Agriculture ; Chemistry ; Food Science & Technology
WOS记录号	WOS:000225358900013
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/23592]
专题	生态环境研究中心_中国科学院环境生物技术重点实验室
推荐引用方式 GB/T 7714	Zhu, XF,Zhang, HX,Lo, R. Phenolic compounds from the leaf extract of artichoke (Cynara scolymus L.) and their antimicrobial activities[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2004,52(24):7272-7278.
APA	Zhu, XF,Zhang, HX,&Lo, R.(2004).Phenolic compounds from the leaf extract of artichoke (Cynara scolymus L.) and their antimicrobial activities.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,52(24),7272-7278.
MLA	Zhu, XF,et al."Phenolic compounds from the leaf extract of artichoke (Cynara scolymus L.) and their antimicrobial activities".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 52.24(2004):7272-7278.