Benzotriazole ultraviolet stabilizers alter the expression of the thyroid hormone pathway in zebrafish (Danio rerio) embryos

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境水质学国家重点实验室

	Benzotriazole ultraviolet stabilizers alter the expression of the thyroid hormone pathway in zebrafish (Danio rerio) embryos
	Liang, Xuefang; Li, Jiajia; Martyniuk, Christopher J.; Wang, Juan; Mao, Yufeng; Lu, Huan; Zha, Jinmiao
刊名	CHEMOSPHERE
	2017-09-01
卷号	182 期号:0 页码:22-30
关键词	Benzotriazole Ultraviolet Stabilizers Thyroid Hormone Receptor Hpt Axis-related Genes Zebrafish Toxicological Pathways
英文摘要	Benzotriazole ultraviolet stabilizers (BUVSs) are widely used in industrial products as well as personal hygiene products to protect the material or skin from harmful UV-radiation. Due to their persistence and bioaccumulation, BUVSs have been ubiquitously detected in aquatic environments. Although the toxicological effects of BUVSs in aquatic organisms have been previously examined, the effects of BUVSs on the thyroid system have not been adequately addressed. In this study, we assessed putative thyroid disrupting effects of BUVSs (UV-234, UV-326, UV-329 and UV-P) in zebrafish embryos at 1, 10 and 100 mu/L for 96 h. The heart rate was assessed in zebrafish and was observed to be decreased by 6.9% -21.4% in exposure of tested BUVSs. We also observed that the transcript levels of HPT axis-related genes were affected by the 4 BUVSs tested in different ways. Specifically, mRNA levels of thyroid hormone receptors (thraa and thrb) in zebrafish embryos were differentially expressed and the direction of change in these transcripts was isoform and BUVSs dependent. Pathway analysis of the targeted genes measured indicated that cellular processes putatively affected by BUVSs included response to organic substance, regulation of transcription from RNA polymerase II promoter, intracellular receptor signaling pathway, and hypothyroidism. Upon expansion of the network, novel genes involved in this predicted gene network may provide insight into the mechanisms of thyroid disrupting mechanisms of BUVSs. Taken together, our results indicate that BUVSs can potentially impact the thyroid system, and that this is dependent upon the type or structure of BUVSs. (C) 2017 Elsevier Ltd. All rights reserved.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/39477]
专题	生态环境研究中心_环境水质学国家重点实验室
推荐引用方式 GB/T 7714	Liang, Xuefang,Li, Jiajia,Martyniuk, Christopher J.,et al. Benzotriazole ultraviolet stabilizers alter the expression of the thyroid hormone pathway in zebrafish (Danio rerio) embryos[J]. CHEMOSPHERE,2017,182(0):22-30.
APA	Liang, Xuefang.,Li, Jiajia.,Martyniuk, Christopher J..,Wang, Juan.,Mao, Yufeng.,...&Zha, Jinmiao.(2017).Benzotriazole ultraviolet stabilizers alter the expression of the thyroid hormone pathway in zebrafish (Danio rerio) embryos.CHEMOSPHERE,182(0),22-30.
MLA	Liang, Xuefang,et al."Benzotriazole ultraviolet stabilizers alter the expression of the thyroid hormone pathway in zebrafish (Danio rerio) embryos".CHEMOSPHERE 182.0(2017):22-30.