Synthesis of different-sized gold nanostars for Raman bioimaging and photothermal therapy in cancer nanotheranostics

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Synthesis of different-sized gold nanostars for Raman bioimaging and photothermal therapy in cancer nanotheranostics
	Liu, Sijin; Gao, Jie; Sanchez-Purra, Maria; Huang, Hao; Wang, Shunhao; Chen, Yunan; Yu, Xuefeng; Luo, Qian; Hamad-Schifferli, Kimberly
刊名	SCIENCE CHINA-CHEMISTRY
	2017-11-01
卷号	60 期号:9 页码:1219-1229
关键词	Gold Nanoparticle Nanostar Surface Plasmon Resonance Tissue Distribution Toxicity Profile
英文摘要	Gold nanoparticles (AuNPs) have been attractive for nanomedicine because of their pronounced optical properties. Here, we customerized the methods to synthesize two types of gold nanostars, Au nanostars-1 and Au nanostars-2, which have different spire lengths and optical properties, and also spherical AuNPs. Compared to nanospheres, gold nanostars were less toxic to a variety of cells, including macrophages. Au nanostars-1 and Au nanostars-2 also manifested a similar pattern of tissue distribution upon in vivo administration in mice to that of nanospheres, and but reveled less liver retention than nanospheres. Due to their strong absorption in the near-infrared (NIR), Au nanostars-2 induced a strong hyperthermia effect in vitro upon excitation at 808 nm, and elicited a robust photothermal therapy (PTT) efficacy in ablating tumors in a mouse model of orthotopic breast cancer using 4T1 breast cancer cells. Meanwhile, Au nanostars-1 showed a great capability to enhance the Raman signal through surface-enhanced Raman spectroscopy (SERS) in 4T1 cells. Our combined results opened a new avenue to develop Au nanostars for cancer imaging and therapy.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/39426]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Liu, Sijin,Gao, Jie,Sanchez-Purra, Maria,et al. Synthesis of different-sized gold nanostars for Raman bioimaging and photothermal therapy in cancer nanotheranostics[J]. SCIENCE CHINA-CHEMISTRY,2017,60(9):1219-1229.
APA	Liu, Sijin.,Gao, Jie.,Sanchez-Purra, Maria.,Huang, Hao.,Wang, Shunhao.,...&Hamad-Schifferli, Kimberly.(2017).Synthesis of different-sized gold nanostars for Raman bioimaging and photothermal therapy in cancer nanotheranostics.SCIENCE CHINA-CHEMISTRY,60(9),1219-1229.
MLA	Liu, Sijin,et al."Synthesis of different-sized gold nanostars for Raman bioimaging and photothermal therapy in cancer nanotheranostics".SCIENCE CHINA-CHEMISTRY 60.9(2017):1219-1229.