Susceptibility of Overweight Mice to Liver Injury as a Result of the ZnO Nanoparticle-Enhanced Liver Deposition of Pb2+

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Susceptibility of Overweight Mice to Liver Injury as a Result of the ZnO Nanoparticle-Enhanced Liver Deposition of Pb2+
	Jiang, Guibin; Jia, Jianbo; Li, Feifei; Zhai, Shumei; Zhou, Hongyu; Liu, Sijin; Yan, Bing
刊名	ENVIRONMENTAL SCIENCE & TECHNOLOGY
	2017-11-01
卷号	51 期号:3 页码:1775-1784
英文摘要	The prevalence of the applications of nanomaterials in consumer products and water treatment facilities increases the chance that humans will be exposed to both nanoparticles and environmental pollutants such as heavy metals. Co-exposure to nanoparticles and heavy metals may adversely affect human health, especially in susceptible populations such as overweight subjects. To evaluate the impact of such co-exposures, we orally administered zinc oxide nanoparticles (ZNPs; 14 or 58 nm) and/or Pb(Ac)(2) at tolerable doses to both healthy overweight and healthy normal weight mice. The ZNPs enhanced the deposition of Pb in all major organs in the overweight mice compared with that in the normal mice. As a result, higher levels of hepatic reactive oxygen species, pro-inflammatory cytokines, and liver injury were observed in the overweight mice but not in the normal weight mice. Our findings underscore a potentially enhanced risk of nanoparticle/heavy metal co-exposure in the susceptible overweight population.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/39425]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Jiang, Guibin,Jia, Jianbo,Li, Feifei,et al. Susceptibility of Overweight Mice to Liver Injury as a Result of the ZnO Nanoparticle-Enhanced Liver Deposition of Pb2+[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2017,51(3):1775-1784.
APA	Jiang, Guibin.,Jia, Jianbo.,Li, Feifei.,Zhai, Shumei.,Zhou, Hongyu.,...&Yan, Bing.(2017).Susceptibility of Overweight Mice to Liver Injury as a Result of the ZnO Nanoparticle-Enhanced Liver Deposition of Pb2+.ENVIRONMENTAL SCIENCE & TECHNOLOGY,51(3),1775-1784.
MLA	Jiang, Guibin,et al."Susceptibility of Overweight Mice to Liver Injury as a Result of the ZnO Nanoparticle-Enhanced Liver Deposition of Pb2+".ENVIRONMENTAL SCIENCE & TECHNOLOGY 51.3(2017):1775-1784.