Biological effects of new-generation dialkyl phosphinate flame retardants and their hydrolysates in BALB/C mice

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Biological effects of new-generation dialkyl phosphinate flame retardants and their hydrolysates in BALB/C mice
	Niu, Yumin; Liang, Yong; Liu, Jingfu; Bao, Jieqing; Liu, Yuchen; Li, Lisha; Chen, Minjie; Liu, Jiyan
刊名	ENVIRONMENTAL TOXICOLOGY
	2017-03-07
卷号	32 期号:5 页码:1578-1586
关键词	Balb c Mice Toxicity Dialkyl Phosphinates Dialkyl Phosphinic Acid
英文摘要	Aluminum methylcyclohexylphosphinate (AMHP), calcium methylcyclohexylphosphinate (CMHP), aluminum diethylphosphinate (ADEP), and aluminum methylethylphosphinate (AMEP) are organic dialkyl phosphinates (DPs) and emerging phosphorus-based flame retardants. The broad-spectrum DPs flame retardants occupy high-end industrial markets, but their ecologic risk has been reported rarely. By exposing male BALB/c mice to DPs and dialkyl phosphinic acids, we studied the toxic effects of these chemicals, and measured AMHP and methylcyclohexylphosphinic acid (MHPA) in blood and feces. We found that DPs and their main hydrolysates had mild toxicity in BALB/c mice. Exposure to 10 and 50 mg/kg/d of AMEP and ADEP caused mild hepatotoxicity in mice. Toxicity of CMHP was in the liver and kidneys. Toxicity of AMHP and its hydrolysate MHPA was low and affected the liver. These data suggest that AMHP has lower toxicity than the other DPs that we tested. (c) 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1578-1586, 2017.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/39258]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Niu, Yumin,Liang, Yong,Liu, Jingfu,et al. Biological effects of new-generation dialkyl phosphinate flame retardants and their hydrolysates in BALB/C mice[J]. ENVIRONMENTAL TOXICOLOGY,2017,32(5):1578-1586.
APA	Niu, Yumin.,Liang, Yong.,Liu, Jingfu.,Bao, Jieqing.,Liu, Yuchen.,...&Liu, Jiyan.(2017).Biological effects of new-generation dialkyl phosphinate flame retardants and their hydrolysates in BALB/C mice.ENVIRONMENTAL TOXICOLOGY,32(5),1578-1586.
MLA	Niu, Yumin,et al."Biological effects of new-generation dialkyl phosphinate flame retardants and their hydrolysates in BALB/C mice".ENVIRONMENTAL TOXICOLOGY 32.5(2017):1578-1586.