Long noncoding RNA SMRG regulates Drosophila macrochaetes by antagonizing scute through E(spl)m | |
Xu, Mengbo1; Xiang, Yuanhang1,2; Liu, Xiaojun3,4; Bai, Baoyan5; Chen, Runsheng5; Liu, Li1,2,6![]() | |
刊名 | RNA BIOLOGY
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2019-01-02 | |
卷号 | 16期号:1页码:42-53 |
关键词 | Mechanoreceptor development long noncoding RNA Drosophila |
ISSN号 | 1547-6286 |
DOI | 10.1080/15476286.2018.1556148 |
产权排序 | 1 |
文献子类 | article |
英文摘要 | It is obvious that the majority of cellular transcripts are long noncoding RNAs (lncRNAs). Although studies suggested that lncRNAs participate in many biological processes through diverse mechanisms, however, little is known about their effects on epidermal mechanoreceptors. Here, we identified one novel Drosophila lncRNA, Scutellar Macrochaetes Regulatory Gene (SMRG), which regulates scutellar macrochaetes that act as mechanoreceptors by antagonizing the proneural gene scute (sc), through the repressor Enhancer-of-split m (E(spl)m). SMRG deficiency induced supernumerary scutellar macrochaetes and simultaneously a high sc RNA level in the adult thorax. Genetically, sc overexpression enhanced this supernumerary phenotype, while heterozygous sc mutant rescued this phenotype, both of which were mediated by E(spl)m. At the molecular level, SMRG recruited E(spl)m to the sc promoter region, which in turn suppressed sc expression. Our work presents a novel function of lncRNA and offers insights into the molecular mechanism underlying mechanoreceptor development. |
WOS关键词 | PRONEURAL CLUSTERS ; GENE-COMPLEX ; ACHAETE ; EXPRESSION ; TRANSCRIPTION ; CHROMATIN ; PROTEINS ; PATTERN ; SYSTEM ; NOTCH |
WOS研究方向 | Biochemistry & Molecular Biology |
语种 | 英语 |
出版者 | TAYLOR & FRANCIS INC |
WOS记录号 | WOS:000459050300005 |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/28400] ![]() |
专题 | 心理研究所_脑与认知科学国家重点实验室 |
通讯作者 | Liu, Li; Li, Meixia |
作者单位 | 1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China 3.Chinese Acad Med Sci, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing, Peoples R China 4.Peking Union Med Coll, Sch Basic Med, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Biophys, Key Lab Noncoding RNA, Beijing, Peoples R China 6.Chinese Acad Sci, Key Lab Mental Hlth, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Xu, Mengbo,Xiang, Yuanhang,Liu, Xiaojun,et al. Long noncoding RNA SMRG regulates Drosophila macrochaetes by antagonizing scute through E(spl)m[J]. RNA BIOLOGY,2019,16(1):42-53. |
APA | Xu, Mengbo.,Xiang, Yuanhang.,Liu, Xiaojun.,Bai, Baoyan.,Chen, Runsheng.,...&Li, Meixia.(2019).Long noncoding RNA SMRG regulates Drosophila macrochaetes by antagonizing scute through E(spl)m.RNA BIOLOGY,16(1),42-53. |
MLA | Xu, Mengbo,et al."Long noncoding RNA SMRG regulates Drosophila macrochaetes by antagonizing scute through E(spl)m".RNA BIOLOGY 16.1(2019):42-53. |
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