Synthesis and antimicrobial activities of novel peptide deformylase inhibitors

	Synthesis and antimicrobial activities of novel peptide deformylase inhibitors
	Yin, Ling 1; Xu, Wei-Ren 2; Wang, Zhi-Guo 3; Zhang, Da-Tong 1; Jia, Jiong 1; Ge, Yan-Qing 1; Li, Yan 1; Wang, Jian-Wu 1
刊名	arkivoc
	2010
页码	196-205
关键词	Peptide deformylase inhibitors N-formylhydroxylamine compounds antibacterial activity
ISSN号	1551-7004
中文摘要	a new series of n-formylhydroxylamine compounds were designed, optimized with the autodock 4.0.1 to investigate the interactions between the target compounds and the amino acid residues of the escherichia coli pdf center dot ni enzyme, and then synthesized through multi-step sequence starting from diethyl malonate. the structures of the compounds were characterized on the basis of spectral (ft-ir, 1h nmr and mass) analysis. all the synthesized compounds have been screened for their antimicrobial activities. it was found that the compounds 11c, 11d, 11f and 11g exhibited potent inhibitory activity against s. aureus in vitro.
英文摘要	a new series of n-formylhydroxylamine compounds were designed, optimized with the autodock 4.0.1 to investigate the interactions between the target compounds and the amino acid residues of the escherichia coli pdf center dot ni enzyme, and then synthesized through multi-step sequence starting from diethyl malonate. the structures of the compounds were characterized on the basis of spectral (ft-ir, 1h nmr and mass) analysis. all the synthesized compounds have been screened for their antimicrobial activities. it was found that the compounds 11c, 11d, 11f and 11g exhibited potent inhibitory activity against s. aureus in vitro.
WOS标题词	science & technology ; physical sciences
类目[WOS]	chemistry, organic
研究领域[WOS]	chemistry
关键词[WOS]	target ; bb-3497 ; protein
收录类别	SCI
语种	英语
WOS记录号	WOS:000282479700019
公开日期	2011-12-13
内容类型	期刊论文
源URL	[http://ir.nwipb.ac.cn//handle/363003/1784]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
作者单位	1.Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China 2.Pharmaceut Res Inst, Tianjin 300193, Peoples R China 3.Chinese Acad Sci, NW Inst Plateau Biol, Xining 810001, Peoples R China
推荐引用方式 GB/T 7714	Yin, Ling,Xu, Wei-Ren,Wang, Zhi-Guo,et al. Synthesis and antimicrobial activities of novel peptide deformylase inhibitors[J]. arkivoc,2010:196-205.
APA	Yin, Ling.,Xu, Wei-Ren.,Wang, Zhi-Guo.,Zhang, Da-Tong.,Jia, Jiong.,...&Wang, Jian-Wu.(2010).Synthesis and antimicrobial activities of novel peptide deformylase inhibitors.arkivoc,196-205.
MLA	Yin, Ling,et al."Synthesis and antimicrobial activities of novel peptide deformylase inhibitors".arkivoc (2010):196-205.