Hepatoprotective and toxic characteristics of the whole herb of traditional Tibetan folk medicine Swertia mussotii Franch.

	Hepatoprotective and toxic characteristics of the whole herb of traditional Tibetan folk medicine Swertia mussotii Franch.
	Lv, Ping 1,2; Wei, Lixin 1; Du, Yuzhi 1; Yang, Hongxia 1,2; Peng, Min 1
刊名	journal of medicinal plants research
	2010-04-18
卷号	4 期号:8 页码:706-709
关键词	Swertia mussotii Franch. Gentianaceae Tibetan herb extracts hepatoprotective activity toxicity
ISSN号	1996-0875
中文摘要	swertia mussotii franch. (sm) (gentianaceae) was a traditional tibetan folk herb for hepatitis in the qinghai-tibet plateau areas. for understanding the hepatoprotection and toxicity characteristics of swertia mussotii franch., the whole plant of swertia mussotii was extracted by water (sme-b) and 75% ethanol (sme-a); then, sme-a was dissolved with water, the supernatant was sme-c, and the sedimentation was sme-d. 17.76% sme-a, 14.48% sme-b, 10.13% sme-c, and 4.35% sme-d were extracted from swertia mussotii. these four extracts were evaluated with acute toxicity and hepatoprotective effect on ccl(4)-induced acute liver damage in mice. the toxic material mainly reside in sme-c and sme-a. the hepatoprotective materials were in sme-a, sme-c and sme-d, while sme-b had no hepatoprotective activities. so, sme-a and sme-c had both the hepatoprotection and toxicity characteristics; sme-b had no toxicity or the hepatoprotection characteristics; only sme-d was hepatoprotective function without toxicity, which could be a good candidate for new drug healing the live disorder.
英文摘要	swertia mussotii franch. (sm) (gentianaceae) was a traditional tibetan folk herb for hepatitis in the qinghai-tibet plateau areas. for understanding the hepatoprotection and toxicity characteristics of swertia mussotii franch., the whole plant of swertia mussotii was extracted by water (sme-b) and 75% ethanol (sme-a); then, sme-a was dissolved with water, the supernatant was sme-c, and the sedimentation was sme-d. 17.76% sme-a, 14.48% sme-b, 10.13% sme-c, and 4.35% sme-d were extracted from swertia mussotii. these four extracts were evaluated with acute toxicity and hepatoprotective effect on ccl(4)-induced acute liver damage in mice. the toxic material mainly reside in sme-c and sme-a. the hepatoprotective materials were in sme-a, sme-c and sme-d, while sme-b had no hepatoprotective activities. so, sme-a and sme-c had both the hepatoprotection and toxicity characteristics; sme-b had no toxicity or the hepatoprotection characteristics; only sme-d was hepatoprotective function without toxicity, which could be a good candidate for new drug healing the live disorder.
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	chemistry, medicinal
研究领域[WOS]	pharmacology & pharmacy
收录类别	SCI
语种	英语
WOS记录号	WOS:000277845700014
公开日期	2011-12-13
内容类型	期刊论文
源URL	[http://ir.nwipb.ac.cn//handle/363003/1720]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
作者单位	1.Chinese Acad Sci, NW Inst Plateau Biol, Xining 810001, Qinghai, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Lv, Ping,Wei, Lixin,Du, Yuzhi,et al. Hepatoprotective and toxic characteristics of the whole herb of traditional Tibetan folk medicine Swertia mussotii Franch.[J]. journal of medicinal plants research,2010,4(8):706-709.
APA	Lv, Ping,Wei, Lixin,Du, Yuzhi,Yang, Hongxia,&Peng, Min.(2010).Hepatoprotective and toxic characteristics of the whole herb of traditional Tibetan folk medicine Swertia mussotii Franch..journal of medicinal plants research,4(8),706-709.
MLA	Lv, Ping,et al."Hepatoprotective and toxic characteristics of the whole herb of traditional Tibetan folk medicine Swertia mussotii Franch.".journal of medicinal plants research 4.8(2010):706-709.