| A carrier-free nanostructure based on platinum(iv) prodrug enhances cellular uptake and cytotoxicity | |
| Tan, Jingjie1,2; Li, Chan2,3; Wang, Qian2; Li, Shuyi2; Chen, Shizhu2,4; Zhang, Jinchao4; Wang, Paul C.5; Ren, Lei1; Liang, Xing-Jie2 | |
| 刊名 | Molecular pharmaceutics
 |
| 2018-04-01 | |
| 卷号 | 15期号:4页码:1724-1728 |
| 关键词 | Cisplatin Nanostructure Carrier-free Cyclooxygenase inhibitor Cellular uptake |
| ISSN号 | 1543-8384 |
| DOI | 10.1021/acs.molpharmaceut.8b00070 |
| 通讯作者 | Li, chan(lichanster@163.com) ; Ren, lei(renlei@xmu.edu.cn) ; Liang, xing-jie(liangxj@nanoctr.cn) |
| 英文摘要 | Flurbiprofen, a hydrophobic cox inhibitor, was coordinated axially with oxoplatin to form a new conjugate, cis,cis,trans-[pt(iv)(nh3)(2)cl-2(flurbiprofen)(2)]. the successful synthesis of this new conjugate was confirmed by h-1, c-13, and pt-195 nmr. the potential of this conjugate being reduced to cisplatin and subsequently exerting its dna cross-linking ability was verified using cyclic voltammetry (cv), hplc, and mass spectrometry (ms). this conjugate showed markedly higher cytotoxicity on many cancer cell lines than cisplatin, flurbiprofen, and their physical mixture (mole ratio, cisplatin:flurbiprofen = 1:2). this is consistent with the result of an apoptosisinducing assay. this conjugate spontaneously assembles carrier-free nanopartides in aqueous solution, which is confirmed by dls, tem, sem, and afm, and thus facilitates cellular uptake and markedly improves its cytotoxicity and apoptosis-inducing ability in vitro. |
| WOS关键词 | EMISSION AIE CHARACTERISTICS ; CISPLATIN RESISTANCE ; CANCER-CELLS ; TUMOR-CELLS ; IN-SITU ; CYCLOOXYGENASE INHIBITORS ; DRUG ACTIVATION ; ASPIRIN ; NANOPARTICLES ; DELIVERY |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| WOS类目 | Medicine, Research & Experimental ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000429283300035 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2178136 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Li, Chan; Ren, Lei; Liang, Xing-Jie |
| 作者单位 | 1.Xiamen Univ, Coll Mat, Key Lab Biomed Engn Fujian Prov, Dept Biomat, Xiamen 361005, Peoples R China 2.Chinese Acad Sci, Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China 3.Peking Univ, Sch Life Sci, Beijing 100871, Peoples R China 4.Hebei Univ, Coll Chem & Environm Sci, Baoding 071002, Peoples R China 5.Howard Univ, Dept Radiol, Washington, DC 20060 USA |
| 推荐引用方式 GB/T 7714 | Tan, Jingjie,Li, Chan,Wang, Qian,et al. A carrier-free nanostructure based on platinum(iv) prodrug enhances cellular uptake and cytotoxicity[J]. Molecular pharmaceutics,2018,15(4):1724-1728. |
| APA | Tan, Jingjie.,Li, Chan.,Wang, Qian.,Li, Shuyi.,Chen, Shizhu.,...&Liang, Xing-Jie.(2018).A carrier-free nanostructure based on platinum(iv) prodrug enhances cellular uptake and cytotoxicity.Molecular pharmaceutics,15(4),1724-1728. |
| MLA | Tan, Jingjie,et al."A carrier-free nanostructure based on platinum(iv) prodrug enhances cellular uptake and cytotoxicity".Molecular pharmaceutics 15.4(2018):1724-1728. |
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