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	Dual drug backboned shattering polymeric theranostic nanomedicine for synergistic eradication of patient-derived lung cancer
	Cong, Yuwei1,2; Xiao, Haihua1,2; Xiong, Hejian1; Wang, Zigui1,3; Ding, Jianxun4; Li, Chan5,6; Chen, Xuesi4; Liang, Xing-Jie5,6; Zhou, Dongfang1; Huang, Yubin1
刊名	Advanced materials
	2018-03-15
卷号	30期号:11页码:11
关键词	Computer tomography Drug delivery Nanomedicine Shattering polymers
ISSN号	0935-9648
DOI	10.1002/adma.201706220
通讯作者	Chen, xuesi(xschen@ciac.ac.cn) ; Liang, xing-jie(liangxj@nanoctr.cn) ; Zhou, dongfang(east@ciac.ac.cn)
英文摘要	Most of the current nanoparticle-based therapeutics worldwide failing in clinical trials face three major challenges: (i) lack of an optimum drug delivery platform with precise composition, (ii) lack of a method of directly monitoring the fate of a specific drug rather than using any other labelling molecules as a compromise, and (iii) lack of reliable cancer models with high fidelity for drug screen and evaluation. here, starting from a pp2a inhibitor demethylcantharidin (dmc) and cisplatin, the design of a dual sensitive dual drug backboned shattering polymer (ddbsp) with exact composition at a fixed dmc/pt ratio for precise nanomedicine is shown. ddbsp self-assembled nanoparticle (dd-np) can be triggered intracellularly to break down in a chain-shattering manner to release the dual drugs payload. moreover, dd-np with extremely high pt heavy metal content in the polymer chain can directly track the drug itself via pt-based drug-mediated computer tomography and icp-ms both in vitro and in vivo. finally, dd-np is used to eradicate the tumor burden on a high-fidelity patient-derived lung cancer model for the first time.
WOS关键词	IMPROVED TUMOR PENETRATION ; IN-VIVO ; NANOPARTICLE DELIVERY ; CO-DELIVERY ; THERAPY ; XENOGRAFTS ; CHEMOTHERAPY ; COMBINATION ; PRODRUG ; MODELS
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000427111300022
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2178094
专题	高能物理研究所
通讯作者	Chen, Xuesi; Liang, Xing-Jie; Zhou, Dongfang
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China 4.Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Jilin, Peoples R China 5.Chinese Acad Sci, Ctr Excellence Nanosci, Beijing 100190, Peoples R China 6.Chinese Acad Sci, Lab Controllable Nanopharmaceut, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Cong, Yuwei,Xiao, Haihua,Xiong, Hejian,et al. Dual drug backboned shattering polymeric theranostic nanomedicine for synergistic eradication of patient-derived lung cancer[J]. Advanced materials,2018,30(11):11.
APA	Cong, Yuwei.,Xiao, Haihua.,Xiong, Hejian.,Wang, Zigui.,Ding, Jianxun.,...&Huang, Yubin.(2018).Dual drug backboned shattering polymeric theranostic nanomedicine for synergistic eradication of patient-derived lung cancer.Advanced materials,30(11),11.
MLA	Cong, Yuwei,et al."Dual drug backboned shattering polymeric theranostic nanomedicine for synergistic eradication of patient-derived lung cancer".Advanced materials 30.11(2018):11.

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