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	Direct site-specific treatment of skin cancer using doxorubicin-loaded nanofibrous membranes
	Guo, Mengyu1,2,4; Zhou, Guoqiang3; Liu, Zhu3; Liu, Jing1,2; Tang, Jinglong1,2; Xiao, Yating4; Xu, Wenshi3; Liu, Ying1,2; Chen, Chunying1,2,4
刊名	Science bulletin
	2018-01-30
卷号	63期号:2页码:92-100
关键词	Core-shell nanofiber Melanoma Electrospinning Controlled drug release
ISSN号	2095-9273
DOI	10.1016/j.scib.2017.11.018
通讯作者	Liu, ying(liuy@nanoctr.cn) ; Chen, chunying(chenchy@nanoctr.cn)
英文摘要	Doxorubicin (dox) is widely used in cancer therapy. however, its application is sometimes limited by its adverse cardiotoxicity and delivery pathways. in our study, we prepared a topical implantable delivery device for controlled drug release and site-specific treatment. the core region consisted of poly (lactic co-glycolic acid) and poly-caprolactone, whereas the shell region was composed of cross-linked gelatin. dox was enclosed in the core region of a core-shell nanofiber obtained by electrospinning. this implantable delivery device was implanted on the top of the melanoma in a mouse model, which had shown a dox-controlled release profile with sustained and sufficient local concentration against melanoma growth in mice with negligible side effects. compared with the traditional intravenous administration, the implantable device allows precisely localized treatment and therefore can reduce the dose, decrease the injection frequency, and ensure antitumor efficacy associated with lower side effects to normal tissues. using a coaxial electrospinning process, it is promising to deliver different hydrophobic or hydrophilic drugs for direct tumor site-specific therapy without large systemic doses and minimized systemic toxicity. (c) 2017 science china press. published by elsevier b.v. and science china press. all rights reserved.
WOS关键词	DRUG-DELIVERY ; NANOPARTICLES ; CHEMOTHERAPY ; THERAPY ; STRATEGIES ; CISPLATIN ; DIAGNOSIS ; EFFICIENT ; RESECTION ; TOXICITY
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
语种	英语
出版者	SCIENCE PRESS
WOS记录号	WOS:000425945900005
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2178061
专题	高能物理研究所
通讯作者	Liu, Ying; Chen, Chunying
作者单位	1.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China 3.Hebei Univ, Coll Chem & Environm Sci, Minist Educ, Key Lab Med Chem & Mol Diag, Baoding 050011, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Guo, Mengyu,Zhou, Guoqiang,Liu, Zhu,et al. Direct site-specific treatment of skin cancer using doxorubicin-loaded nanofibrous membranes[J]. Science bulletin,2018,63(2):92-100.
APA	Guo, Mengyu.,Zhou, Guoqiang.,Liu, Zhu.,Liu, Jing.,Tang, Jinglong.,...&Chen, Chunying.(2018).Direct site-specific treatment of skin cancer using doxorubicin-loaded nanofibrous membranes.Science bulletin,63(2),92-100.
MLA	Guo, Mengyu,et al."Direct site-specific treatment of skin cancer using doxorubicin-loaded nanofibrous membranes".Science bulletin 63.2(2018):92-100.

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