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	Impact of titanium dioxide and fullerenol nanoparticles on caco-2 gut epithelial cells
	Yang, Shengmei1,2; Xiong, Fengxia2; Chen, Kui2; Chang, Yanan2; Bai, Xue2; Yin, Wenyan2; Gu, Weihong2; Wang, Qianyuan2; Li, Juan2; Chen, Guogang1
刊名	Journal of nanoscience and nanotechnology
	2018-04-01
卷号	18期号:4页码:2387-2393
关键词	Caco-2 gut epithelial cells Titanium dioxide Fullerenol Nanoparticles
ISSN号	1533-4880
DOI	10.1166/jnn.2018.14540
通讯作者	Li, juan() ; Chen, guogang()
英文摘要	The application of nano-products in the food industry increases the risk of people exposed to nanoparticles. titanium dioxide nanoparticles (t-nps) are typically and widely used in food field, while fullerenol nanoparticles (f-nps) have great promise to be used as food additives. therefore, it is necessary and important to understand the safety of t-nps and f-nps in foods. in the present study, caco-2 gut epithelial cell line was selected as a model to investigate the impact of t-nps and f-nps. the viability and proliferation of caco-2 gut epithelial cells incubated with different concentrations of t-nps and f-nps were observed. the results showed that the two kinds of nanoparticles did not induce cell death even lasting for 48 h. the results of apoptosis and dna damages in the cells indicated that both t-nps with 50 and 100 mu g/ml caused caco-2 gut epithelial cell apoptosis, but didn't cause significantly dna damages. f-nps with 200 and 500 mu g/ml concentrations also can induce cell apoptosis but no dna damage.
WOS关键词	ROS
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
语种	英语
出版者	AMER SCIENTIFIC PUBLISHERS
WOS记录号	WOS:000426050500016
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2178005
专题	高能物理研究所
通讯作者	Li, Juan; Chen, Guogang
作者单位	1.ShiHezi Univ, Coll Food Sci, Shihezi 832000, Peoples R China 2.Chinese Acad Sci, Inst High Energy Phys, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Yang, Shengmei,Xiong, Fengxia,Chen, Kui,et al. Impact of titanium dioxide and fullerenol nanoparticles on caco-2 gut epithelial cells[J]. Journal of nanoscience and nanotechnology,2018,18(4):2387-2393.
APA	Yang, Shengmei.,Xiong, Fengxia.,Chen, Kui.,Chang, Yanan.,Bai, Xue.,...&Chen, Guogang.(2018).Impact of titanium dioxide and fullerenol nanoparticles on caco-2 gut epithelial cells.Journal of nanoscience and nanotechnology,18(4),2387-2393.
MLA	Yang, Shengmei,et al."Impact of titanium dioxide and fullerenol nanoparticles on caco-2 gut epithelial cells".Journal of nanoscience and nanotechnology 18.4(2018):2387-2393.

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