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	Tunable self-assembly of irinotecan-fatty acid prodrugs with increased cytotoxicity to cancer cells
	Zhang, Chunqiu1,2; Jin, Shubin1,2; Xue, Xiangdong1,2; Zhang, Tingbin1,2; Jiang, Yonggang1,2; Wang, Paul C.3,4; Liang, Xing-Jie1,2
刊名	Journal of materials chemistry b
	2016
卷号	4期号:19页码:3286-3291
ISSN号	2050-750X
DOI	10.1039/c6tb00612d
通讯作者	Wang, paul c.(pwang@howard.edu) ; Liang, xing-jie(liangxj@nanoctr.cn)
英文摘要	The development of a clinical chemotherapeutic is not an easy task. one challenge is how to deliver the agent to cancer cells. nano-formulation of prodrugs, which combines the strengths of nanotechnology and prodrugs, possesses many advantages for chemotherapeutic drug delivery, including high drug loading efficiency, improved drug availability and enhanced accumulation in cancer cells. here, we have constructed a small library of irinotecan-derived prodrugs, in which the 20-hydroxyl group was derived with fatty-acid moieties through esterification. this conjugation fine-tuned the polarity of the irinotecan molecule, thus enhancing the lipophilicity of the prodrugs and inducing their self-assembly into nanoparticles with different morphologies. these nano-formulated prodrugs accumulated at higher levels in cancer cells and were much more cytotoxic than free drugs. the rational design of prodrug-based nano-formulations opens a new avenue for the engineering of more efficient drug-delivery systems.
WOS关键词	DRUG-DELIVERY ; CONJUGATE NANOPARTICLES ; IN-VITRO ; THERAPY ; NANOTECHNOLOGY ; TUMORS ; VERSATILE ; PLATFORM ; VIVO
WOS研究方向	Materials Science
WOS类目	Materials Science, Biomaterials
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000376039100013
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2177776
专题	高能物理研究所
通讯作者	Wang, Paul C.; Liang, Xing-Jie
作者单位	1.Chinese Acad Sci, Ctr Excellence Nanosci, 11 Beiyitiao, Beijing 100190, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, 11 Beiyitiao, Beijing 100190, Peoples R China 3.Fu Jen Catholic Univ, Taipei 24205, Taiwan 4.Howard Univ, Dept Radiol, Lab Mol Imaging, Washington, DC 20060 USA
推荐引用方式 GB/T 7714	Zhang, Chunqiu,Jin, Shubin,Xue, Xiangdong,et al. Tunable self-assembly of irinotecan-fatty acid prodrugs with increased cytotoxicity to cancer cells[J]. Journal of materials chemistry b,2016,4(19):3286-3291.
APA	Zhang, Chunqiu.,Jin, Shubin.,Xue, Xiangdong.,Zhang, Tingbin.,Jiang, Yonggang.,...&Liang, Xing-Jie.(2016).Tunable self-assembly of irinotecan-fatty acid prodrugs with increased cytotoxicity to cancer cells.Journal of materials chemistry b,4(19),3286-3291.
MLA	Zhang, Chunqiu,et al."Tunable self-assembly of irinotecan-fatty acid prodrugs with increased cytotoxicity to cancer cells".Journal of materials chemistry b 4.19(2016):3286-3291.

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