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	Specific detection and effective inhibition of a single bacterial species in situ using peptide mineralized au cluster probes
	Zhang, Xiangchun1,3; Liu, Li1; Liu, Ru1; Wang, Jing1; Hu, Xuhu1; Yuan, Qing1; Guo, Juanjuan1; Xing, Gengmei1; Zhao, Yuliang1; Gao, Xueyun1,2
刊名	Science china-chemistry
	2018-05-01
卷号	61期号:5页码:627-634
关键词	Au cluster probes Single bacteria species S. aureus Specific detection Effective inhibition
ISSN号	1674-7291
DOI	10.1007/s11426-017-9206-y
通讯作者	Liu, ru(liuru@ihep.ac.cn) ; Gao, xueyun(gaoxy@ihep.ac.cn)
英文摘要	Increasingly serious microbial infections call for the development of new simpler methods for the precise diagnosis and specific inhibition of such pathogens. in this work, a peptide mineralized au cluster probe was applied as a new simplified strategy to both recognize and inhibit a single bacteria species of staphylococcus aureus (s. aureus) simultaneously. the probes are composed of peptides and au clusters. moreover, the peptides specifically target s. aureus cells and the au clusters provide fluorescent imaging and have an antibacterial effect. these new probes enable the simultaneous specific detection and effective destruction s. aureus cells in situ.
WOS关键词	ANTIBIOTIC-RESISTANT BACTERIA ; GRAM-POSITIVE BACTERIA ; STAPHYLOCOCCUS-AUREUS ; GOLD NANOCLUSTERS ; ANTIBACTERIAL APPLICATIONS ; ANTIMICROBIAL AGENTS ; INFECTIOUS-DISEASES ; NANOPARTICLES ; CELL ; PATHOGENS
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
语种	英语
出版者	SCIENCE PRESS
WOS记录号	WOS:000431179300019
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2177599
专题	高能物理研究所
通讯作者	Liu, Ru; Gao, Xueyun
作者单位	1.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China 2.Beijing Univ Technol, Dept Chem & Chem Engn, Beijing 100124, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Xiangchun,Liu, Li,Liu, Ru,et al. Specific detection and effective inhibition of a single bacterial species in situ using peptide mineralized au cluster probes[J]. Science china-chemistry,2018,61(5):627-634.
APA	Zhang, Xiangchun.,Liu, Li.,Liu, Ru.,Wang, Jing.,Hu, Xuhu.,...&Gao, Xueyun.(2018).Specific detection and effective inhibition of a single bacterial species in situ using peptide mineralized au cluster probes.Science china-chemistry,61(5),627-634.
MLA	Zhang, Xiangchun,et al."Specific detection and effective inhibition of a single bacterial species in situ using peptide mineralized au cluster probes".Science china-chemistry 61.5(2018):627-634.

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