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	Oral administration of rutile and anatase tio2 nanoparticles shifts mouse gut microbiota structure
	Li, Juan1; Yang, Shengmei1; Lei, Runhong1; Gu, Weihong1; Qin, Yanxia1; Ma, Sihan1; Chen, Kui1; Chang, Yanan1; Bai, Xue1; Xia, Shibo1
刊名	Nanoscale
	2018-04-28
卷号	10期号:16页码:7736-7745
ISSN号	2040-3364
DOI	10.1039/c8nr00386f
通讯作者	Wu, chongming(cmwu@implad.ac.cn) ; Xing, gengmei(xinggm@ihep.ac.cn)
英文摘要	The widespread application of tio2 nanoparticles (nps) as additives in foods such as gum, candy and puddings has dramatically increased the human ingestion and accumulation of these nanomaterials. although the toxicity of tio2 nps has been extensively studied, their impact on gut microbiota in vivo still needs further research. in this study, tio2 nps with two main crystalline phases anatase and rutile were orally administrated to mice for 28 days. the dynamic influences of anatase and rutile on gut microbiota structures were investigated at doses equivalent to those consumed by people who love to eat candies. the results showed that titanium accumulated in the spleen, lung, and kidney but had no significant effects on organ histology. gavage of rutile nps but not anatase nps resulted in longer intestinal villi and irregular arrangement of villus epithelial cells. treatment with tio2 nps did not decrease gut microbiota diversity but shifted their structures in a time-dependent manner. rutile nps had a more pronounced influence on the gut microbiota than anatase nps. the most influenced phylum was proteobacteria, which was significantly increased by rutile but not by anatase. at the genus level, prevotella was significantly decreased by both the tio2 nps, rhodococcus was enriched by rutile nps, and bacteroides was increased by anatase nps. overall, these results suggested that chronic overconsumption of tio2 np-containing foods is likely to deteriorate the gastrointestinal tract and change the structures of microbiota. the crystalline phases may play an important role in mediating the intestinal impact of tio2 nps.
WOS关键词	TITANIUM-DIOXIDE NANOPARTICLES ; UNDERSTANDING BIOPHYSICOCHEMICAL INTERACTIONS ; FOOD-GRADE ; TOXICITY ; LIVER ; TRANSFORMATION ; GENOTOXICITY ; GENERATION ; PARTICLES ; PRODUCTS
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000431030000048
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2177594
专题	高能物理研究所
通讯作者	Wu, Chongming; Xing, Gengmei
作者单位	1.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China 2.Chinese Acad Med Sci, Inst Med Plant Dev, Pharmacol & Toxicol Res Ctr, Beijing 100193, Peoples R China 3.Peking Union Med Coll, Beijing 100193, Peoples R China
推荐引用方式 GB/T 7714	Li, Juan,Yang, Shengmei,Lei, Runhong,et al. Oral administration of rutile and anatase tio2 nanoparticles shifts mouse gut microbiota structure[J]. Nanoscale,2018,10(16):7736-7745.
APA	Li, Juan.,Yang, Shengmei.,Lei, Runhong.,Gu, Weihong.,Qin, Yanxia.,...&Xing, Gengmei.(2018).Oral administration of rutile and anatase tio2 nanoparticles shifts mouse gut microbiota structure.Nanoscale,10(16),7736-7745.
MLA	Li, Juan,et al."Oral administration of rutile and anatase tio2 nanoparticles shifts mouse gut microbiota structure".Nanoscale 10.16(2018):7736-7745.

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