| Nanomaterial-assisted sensitization of oncotherapy | |
| Wang, Yufei1,2; Liu, Juan3; Ma, Xiaowei1,2; Liang, Xing-Jie1,2 | |
| 刊名 | Nano research
 |
| 2018-06-01 | |
| 卷号 | 11期号:6页码:2932-2950 |
| 关键词 | Nanomaterial Oncotherapy Sensitization of oncotherapy Multidrug resistance |
| ISSN号 | 1998-0124 |
| DOI | 10.1007/s12274-017-1961-0 |
| 通讯作者 | Ma, xiaowei(maxw@nanoctr.cn) ; Liang, xing-jie(liangxj@nanoctr.cn) |
| 英文摘要 | Globally, cancer is growing at an alarming pace, which calls for development of more efficient cancer treatments. conventional chemotherapy and radiotherapy have become crucial first-line clinical treatments for cancer. however, along with their wide usage, limited therapeutic effects, severe adverse reactions, unaffordable costs, and complicated operations lead to failures of these treatments. moreover, the emergence of multidrug resistance inhibits the longtime usage of chemotherapeutics. one of the major causes of treatment failure is the insufficient sensitivity of cancer cells to therapeutic drugs or treatments. with the rigorous development of nanotechnology, tailored nanoparticles can efficiently sensitize malignant cells by inducing intracellular structural and functional changes, which could affect vital intracellular processes such as metabolism, signal conduction, proliferation, cell death as well as intracellular drug delivery. here, we review recent advances in nanomaterial-assisted sensitization of oncotherapy, and challenges and strategies in the development of nanomedical approaches. |
| WOS关键词 | BREAST-CANCER CELLS ; OVERCOMING MULTIDRUG-RESISTANCE ; ENDOPLASMIC-RETICULUM STRESS ; AGGREGATION-INDUCED EMISSION ; TARGETED DRUG-DELIVERY ; NUCLEAR-PORE COMPLEX ; GOLD NANOPARTICLES ; CO-DELIVERY ; TUMOR-CELLS ; ENHANCED RADIOTHERAPY |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
| 语种 | 英语 |
| 出版者 | TSINGHUA UNIV PRESS |
| WOS记录号 | WOS:000433048600003 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2177519 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Ma, Xiaowei; Liang, Xing-Jie |
| 作者单位 | 1.Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Beijing Inst Transfus Med, Tissue Engn Lab, Beijing 100850, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yufei,Liu, Juan,Ma, Xiaowei,et al. Nanomaterial-assisted sensitization of oncotherapy[J]. Nano research,2018,11(6):2932-2950. |
| APA | Wang, Yufei,Liu, Juan,Ma, Xiaowei,&Liang, Xing-Jie.(2018).Nanomaterial-assisted sensitization of oncotherapy.Nano research,11(6),2932-2950. |
| MLA | Wang, Yufei,et al."Nanomaterial-assisted sensitization of oncotherapy".Nano research 11.6(2018):2932-2950. |
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