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	Protein-directed synthesis of bi2s3 nanoparticles as an efficient contrast agent for visualizing the gastrointestinal tract
	Zu, Yan; Yong, Yuan; Zhang, Xiao; Yu, Jie; Dong, Xinghua; Yin, Wenyan; Yan, Liang; Zhao, Feng; Gu, Zhanjun; Zhao, Yuliang
刊名	Rsc advances
	2017
卷号	7期号:28页码:17505-17513
ISSN号	2046-2069
DOI	10.1039/c7ra01526g
通讯作者	Yan, liang()
英文摘要	Non-invasive imaging modalities such as computed tomography are often used for diagnosis and assessment of gastrointestinal (gi) disease status over the long-term. the physiology of the gi tract can be assessed with contrast agents. here, we present common protein (bovine serum albumin, bsa) stabilized bismuth sulfide nanoparticles with robust x-ray attenuation. under the optimal conditions, this agent can outline the anatomy of the mouse gi tract on 3d computed tomography imaging, with the real-time and non-invasive visualization of nanoparticle distribution and the gi tract. moreover, the investigation on long-term toxicity and biodistribution of these nanoparticles after oral administration indicate their overall safety. this is a promising agent for gi visualization and disease diagnosis.
WOS关键词	BISMUTH SULFIDE NANOPARTICLES ; LARGE-SCALE SYNTHESIS ; COMPUTED-TOMOGRAPHY ; IN-VIVO ; ASSISTED SYNTHESIS ; NANODOTS ; NANORODS ; CANCER ; DELIVERY ; THERAPY
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000398802000068
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2177462
专题	高能物理研究所
通讯作者	Yan, Liang
作者单位	Chinese Acad Sci, Inst High Energy Phys, Natl Ctr Nanosci Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zu, Yan,Yong, Yuan,Zhang, Xiao,et al. Protein-directed synthesis of bi2s3 nanoparticles as an efficient contrast agent for visualizing the gastrointestinal tract[J]. Rsc advances,2017,7(28):17505-17513.
APA	Zu, Yan.,Yong, Yuan.,Zhang, Xiao.,Yu, Jie.,Dong, Xinghua.,...&Zhao, Yuliang.(2017).Protein-directed synthesis of bi2s3 nanoparticles as an efficient contrast agent for visualizing the gastrointestinal tract.Rsc advances,7(28),17505-17513.
MLA	Zu, Yan,et al."Protein-directed synthesis of bi2s3 nanoparticles as an efficient contrast agent for visualizing the gastrointestinal tract".Rsc advances 7.28(2017):17505-17513.

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