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	Icam-1-targeted liposomes loaded with liver x receptor agonists suppress pdgf-induced proliferation of vascular smooth muscle cells
	Huang, Xu2; Xu, Meng-Qi2; Zhang, Wei; Ma, Sai2; Guo, Weisheng1,2; Wang, Yabin2; Zhang, Yan2; Gou, Tiantian2; Chen, Yundai2; Liang, Xing-Jie1
刊名	Nanoscale research letters
	2017-05-03
卷号	12页码:9
关键词	Vascular smooth muscle cells Liver x receptor Icam-1 Liposome
ISSN号	1556-276X
DOI	10.1186/s11671-017-2097-6
通讯作者	Liang, xing-jie(liangxj@nanoctr.cn) ; Cao, feng(fengcao8828@163.com)
英文摘要	The proliferation of vascular smooth muscle cells (vsmcs) is one of the key events during the progress of atherosclerosis. the activated liver x receptor (lxr) signalling pathway is demonstrated to inhibit platelet-derived growth factor bb (pdgf-bb)-induced vsmc proliferation. notably, following pdgf-bb stimulation, the expression of intercellular adhesion molecule-1 (icam-1) by vsmcs increases significantly. in this study, anti-icam-1 antibody-conjugated liposomes were fabricated for targeted delivery of a water-insoluble lxr agonist (t0901317) to inhibit vsmc proliferation. the liposomes were prepared by filming-rehydration method with uniform size distribution and considerable drug entrapment efficiency. the targeting effect of the anti-icam-t0901317 liposomes was evaluated by confocal laser scanning microscope (clsm) and flow cytometry. anti-icam-t0901317 liposomes showed significantly higher inhibition effect of vsmc proliferation than free t0901317 by cck8 proliferation assays and brdu staining. western blot assay further confirmed that anti-icam-t0901317 liposomes inhibited retinoblastoma (rb) phosphorylation and mcm6 expression. in conclusion, this study identified anti-icam-t0901317 liposomes as a promising nanotherapeutic approach to overcome vsmc proliferation during atherosclerosis progression.
WOS关键词	DRUG-DELIVERY SYSTEM ; ATHEROSCLEROSIS ; NANOPARTICLES ; CANCER ; EXPRESSION ; MIGRATION ; ICAM-1
WOS研究方向	Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000402769700001
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2177392
专题	高能物理研究所
通讯作者	Liang, Xing-Jie; Cao, Feng
作者单位	1.Natl Ctr Nanosci & Technol, Lab Controllable Nanopharmaceut, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, State Key Lab Kidney Dis, Beijing 100853, Peoples R China
推荐引用方式 GB/T 7714	Huang, Xu,Xu, Meng-Qi,Zhang, Wei,et al. Icam-1-targeted liposomes loaded with liver x receptor agonists suppress pdgf-induced proliferation of vascular smooth muscle cells[J]. Nanoscale research letters,2017,12:9.
APA	Huang, Xu.,Xu, Meng-Qi.,Zhang, Wei.,Ma, Sai.,Guo, Weisheng.,...&Cao, Feng.(2017).Icam-1-targeted liposomes loaded with liver x receptor agonists suppress pdgf-induced proliferation of vascular smooth muscle cells.Nanoscale research letters,12,9.
MLA	Huang, Xu,et al."Icam-1-targeted liposomes loaded with liver x receptor agonists suppress pdgf-induced proliferation of vascular smooth muscle cells".Nanoscale research letters 12(2017):9.

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