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	Strategies for improving drug delivery: nanocarriers and microenvironmental priming
	Khalid, Ayesha1; Persano, Stefano2; Shen, Haifa2,3; Zhao, Yuliang4,5; Blanco, Elvin2; Ferrari, Mauro2,6; Wolfram, Joy2,4
刊名	Expert opinion on drug delivery
	2017
卷号	14期号:7页码:865-877
关键词	Biodistribution Biological barrier Nanodelivery system Priming agents Transport ocophysics
ISSN号	1742-5247
DOI	10.1080/17425247.2017.1243527
通讯作者	Wolfram, joy(jvwolfram@houstonmethodist.org)
英文摘要	Introduction: the ultimate goal in the field of drug delivery is to exclusively direct therapeutic agents to pathological tissues in order to increase therapeutic efficacy and eliminate side effects. this goal is challenging due to multiple transport obstacles in the body. strategies that improve drug transport exploit differences in the characteristics of normal and pathological tissues. within the field of oncology, these concepts have laid the groundwork for a new discipline termed transport oncophysics. areas covered: efforts to improve drug biodistribution have mainly focused on nanocarriers that enable preferential accumulation of drugs in diseased tissues. a less common approach to enhance drug transport involves priming strategies that modulate the biological environment in ways that favor localized drug delivery. this review discusses a variety of priming and nanoparticle design strategies that have been used for drug delivery. expert opinion: combinations of priming agents and nanocarriers are likely to yield optimal drug distribution profiles. although priming strategies have yet to be widely implemented, they represent promising solutions for overcoming biological transport barriers. in fact, such strategies are not restricted to priming the tumor microenvironment but can also be directed toward healthy tissue in order to reduce nanoparticle uptake.
WOS关键词	ALBUMIN-BOUND PACLITAXEL ; ADVANCED PANCREATIC-CANCER ; PHASE-II TRIAL ; PROTEIN CORONA ; IN-VIVO ; SOLID TUMORS ; MACROMOLECULAR THERAPEUTICS ; TUMORITROPIC ACCUMULATION ; TARGETED NANOPARTICLES ; LIPID NANOPARTICLES
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Pharmacology & Pharmacy
语种	英语
出版者	TAYLOR & FRANCIS LTD
WOS记录号	WOS:000404938000004
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2177284
专题	高能物理研究所
通讯作者	Wolfram, Joy
作者单位	1.Qatar Fdn, Program Med, Weill Cornell Med Qatar, Doha, Qatar 2.Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA 3.Weill Cornell Med, Dept Cell & Dev Biol, New York, NY USA 4.Univ Chinese Acad Sci, Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing, Peoples R China 5.Chinese Acad Sci, Inst High Energy Phys, Beijing, Peoples R China 6.Weill Cornell Med, Dept Med, New York, NY USA
推荐引用方式 GB/T 7714	Khalid, Ayesha,Persano, Stefano,Shen, Haifa,et al. Strategies for improving drug delivery: nanocarriers and microenvironmental priming[J]. Expert opinion on drug delivery,2017,14(7):865-877.
APA	Khalid, Ayesha.,Persano, Stefano.,Shen, Haifa.,Zhao, Yuliang.,Blanco, Elvin.,...&Wolfram, Joy.(2017).Strategies for improving drug delivery: nanocarriers and microenvironmental priming.Expert opinion on drug delivery,14(7),865-877.
MLA	Khalid, Ayesha,et al."Strategies for improving drug delivery: nanocarriers and microenvironmental priming".Expert opinion on drug delivery 14.7(2017):865-877.

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