| The application of stimuli-responsive nanocarriers for targeted drug delivery | |
| Zhou, Mengxue; Wen, Kaikai; Bi, Ying; Lu, Huiru; Chen, Jun; Hu, Yi; Chai, Zhifang | |
| 刊名 | Current topics in medicinal chemistry
 |
| 2017 | |
| 卷号 | 17期号:20页码:2319-2334 |
| 关键词 | Stimuli-response Nanoparticles Drug delivery Tumor microenvironment Chemotherapy |
| ISSN号 | 1568-0266 |
| DOI | 10.2174/1568026617666170224121008 |
| 通讯作者 | Chen, jun(chenjun@ihep.ac.cn) |
| 英文摘要 | Nanocarriers are widely used for delivering drugs to tumors and are progressing in a stable trend, because malignant tumors remain a major health burden throughout the world and effective therapeutic strategies are urgently needed. furthermore, as an integrated platform, nanocarriers have the potential to dramatically improve cancer diagnosis, imaging, and therapy, while reducing the toxicity associated with the current approaches. significantly, intelligent nanocarriers are the new generation of the nanocarriers, exhibiting superior tumor targeting and improved therapeutic efficacy. in this review, we discuss recent development in the design of nanoscale stimuli-responsive systems which will be able to control drug biodistribution in response to specific stimuli, either exogenous or endogenous. meanwhile, the recent progress in engineering intelligent and versatile nanomaterials for targeting the tumor microenvironment is summarized. |
| WOS关键词 | MESOPOROUS SILICA NANOPARTICLES ; NEAR-INFRARED LIGHT ; BLOCK-COPOLYMER MICELLES ; ENHANCED INTRACELLULAR DELIVERY ; GENERATING LIPOSOMAL SYSTEM ; CELL-PENETRATING PEPTIDES ; IRON-OXIDE NANOPARTICLES ; TUMOR XENOGRAFT MODEL ; GENE DELIVERY ; CANCER-THERAPY |
| WOS研究方向 | Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Medicinal |
| 语种 | 英语 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| WOS记录号 | WOS:000405625600007 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2177248 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Chen, Jun |
| 作者单位 | Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Multidisciplinary Res Div, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Mengxue,Wen, Kaikai,Bi, Ying,et al. The application of stimuli-responsive nanocarriers for targeted drug delivery[J]. Current topics in medicinal chemistry,2017,17(20):2319-2334. |
| APA | Zhou, Mengxue.,Wen, Kaikai.,Bi, Ying.,Lu, Huiru.,Chen, Jun.,...&Chai, Zhifang.(2017).The application of stimuli-responsive nanocarriers for targeted drug delivery.Current topics in medicinal chemistry,17(20),2319-2334. |
| MLA | Zhou, Mengxue,et al."The application of stimuli-responsive nanocarriers for targeted drug delivery".Current topics in medicinal chemistry 17.20(2017):2319-2334. |
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