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	Unraveling the roles of cd44/cd24 and aldh1 as cancer stem cell markers in tumorigenesis and metastasis
	Li, Wenzhe1,2,3; Ma, Huailei1,3; Zhang, Jin2; Zhu, Ling1,3; Wang, Chen1,3; Yang, Yanlian1,3
刊名	Scientific reports
	2017-10-23
卷号	7页码:15
ISSN号	2045-2322
DOI	10.1038/s41598-017-14364-2
通讯作者	Zhu, ling(zhul@nanoctr.cn) ; Wang, chen(wangch@nanoctr.cn) ; Yang, yanlian(yangyl@nanoctr.cn)
英文摘要	Cd44/cd24 and aldh1 are widely used cancer stem cell (csc) markers in breast cancer. however, their expression is not always consistent even in the same subtype of breast cancer. systematic comparison of their functions is still lacking. we investigated the expression of cd44, cd24 and aldh1 in different subtypes of breast cancer cells, and explored their relationship with cancer progression. we defined a parameter cd44/cd24 ratio to present the expression level of cd44 and cd24 and found that high cd44/cd24 ratio and aldh1(+) are both indicators for cancer malignancy, but play different functions during tumor progression. high cd44/cd24 ratio is more related to cell proliferation and tumorigenesis, which is confirmed by mammosphere formation and tumorigenesis in xenotransplanted mice. aldh1(+) is a stronger indicator for cell migration and tumor metastasis. suppression of cd44 and aldh1 by sirna led to decreased tumorigenicity and cell migration capacity. the combination of high cd44/cd24 ratio and aldh1(+) would be a more reliable way to characterize cscs. moreover, both high cd44/cd24 ratio and aldh1(+) were conserved during metastasis, from the primary tumors to the circulating tumor cells (ctcs) and the distant metastases, suggesting the significant value of these csc markers in assisting cancer detection, prognostic evaluation, and even cancer therapeutics.
WOS关键词	CIRCULATING TUMOR-CELLS ; LYMPH-NODE METASTASES ; NEGATIVE BREAST-CANCER ; ALDEHYDE DEHYDROGENASE ; BONE-MARROW ; IN-VITRO ; EXPRESSION ; IDENTIFICATION ; HETEROGENEITY ; SUBTYPES
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000413401300031
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2177153
专题	高能物理研究所
通讯作者	Zhu, Ling; Wang, Chen; Yang, Yanlian
作者单位	1.Natl Ctr Nanosci & Technol, CAS Key Lab Standardizat & Measurement Nanotechno, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China 3.Univ Chinese Acad Sci, 19 A Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Li, Wenzhe,Ma, Huailei,Zhang, Jin,et al. Unraveling the roles of cd44/cd24 and aldh1 as cancer stem cell markers in tumorigenesis and metastasis[J]. Scientific reports,2017,7:15.
APA	Li, Wenzhe,Ma, Huailei,Zhang, Jin,Zhu, Ling,Wang, Chen,&Yang, Yanlian.(2017).Unraveling the roles of cd44/cd24 and aldh1 as cancer stem cell markers in tumorigenesis and metastasis.Scientific reports,7,15.
MLA	Li, Wenzhe,et al."Unraveling the roles of cd44/cd24 and aldh1 as cancer stem cell markers in tumorigenesis and metastasis".Scientific reports 7(2017):15.

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