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	Structural analysis of wss1 protein from saccharomyces cerevisiae
	Yang, Xiaoyun1; Li, Yanhua2; Gao, Zengqiang2; Li, Zongqiang3; Xu, Jianhua2; Wang, Wenjia4; Dong, Yuhui2
刊名	Scientific reports
	2017-08-15
卷号	7页码:9
ISSN号	2045-2322
DOI	10.1038/s41598-017-08834-w
通讯作者	Wang, wenjia(wangwenjia@ihep.ac.cn) ; Dong, yuhui(dongyh@ihep.ac.cn)
英文摘要	Wss1 is a dna-protein crosslinks (dpcs) repair protein, which is responsible for degradation of the protein components in dpcs. in this investigation, crystal structure of the protease domain from saccharomyces cerevisiae wss1 (scwss1) was solved and was compared with the known crystal structure of schizosaccharomyces prombe wss1 (spwss1). it is found that the cleft near zinc ion to be the most conserved core region of wss1 and that the electronic surface distributions vary greatly between the two homologs. solution architecture of the full-length scwss1 was further investigated by small-angle x-ray scattering (saxs), which indicated the protein contains a flexible region inside. finally, based on the structural information, a mechanism was proposed about how the enzyme is activated by dna substrates.
WOS关键词	CROSS-LINK REPAIR ; DNA-REPAIR ; SCATTERING ; SYSTEM
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000407570000147
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2177026
专题	高能物理研究所
通讯作者	Wang, Wenjia; Dong, Yuhui
作者单位	1.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Anhui, Peoples R China 2.Chinese Acad Sci, Beijing Synchrotron Radiat Facil, Inst High Energy Phys, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Biophys, Key Lab RNA Biol, Beijing 100049, Peoples R China 4.Qilu Univ Technol, Sch Sci, Jinan 250353, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Yang, Xiaoyun,Li, Yanhua,Gao, Zengqiang,et al. Structural analysis of wss1 protein from saccharomyces cerevisiae[J]. Scientific reports,2017,7:9.
APA	Yang, Xiaoyun.,Li, Yanhua.,Gao, Zengqiang.,Li, Zongqiang.,Xu, Jianhua.,...&Dong, Yuhui.(2017).Structural analysis of wss1 protein from saccharomyces cerevisiae.Scientific reports,7,9.
MLA	Yang, Xiaoyun,et al."Structural analysis of wss1 protein from saccharomyces cerevisiae".Scientific reports 7(2017):9.

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