| Pre-synaptic trkb in basolateral amygdala neurons mediates bdnf signaling transmission in memory extinction | |
| Li, Yuan1,2,3; Wang, Dongdong1,2; Li, Yang4; Chu, Hongxia3; Zhang, Lining3; Hou, Ming1; Jiang, Xingyu5; Chen, Zheyu2; Su, Bo2; Sun, Tao1,2 | |
| 刊名 | Cell death & disease
 |
| 2017-07-01 | |
| 卷号 | 8页码:11 |
| ISSN号 | 2041-4889 |
| DOI | 10.1038/cddis.2017.302 |
| 通讯作者 | Su, bo(bxs103@sdu.edu.cn) ; Sun, tao(taosun@sdu.edu.cn) |
| 英文摘要 | Brain-derived neurotrophic factor (bdnf) and its high affinity receptor, trkb, play an essential role in memory extinction. our previous work has shown that jip3 (jnk interacted protein 3) mediates anterograde axonal transport of trkb through the direct binding of its coiled-coil domain 1 (cc1) with trkb. here, we constructed a fluorescent cc1 and enhanced green fluorescent protein (egfp) fused protein, cc1-egfp, and found that cc1-egfp could specifically interrupt trkb anterograde axonal transport and its localization at the pre-synaptic site. consistent with this, trkb-mediated pre-synaptic vesicle release and retrograde axonal signaling transmission were disrupted by cc1-egfp. neuronal expression of cc1-egfp in the basolateral amygdala (bla) impaired fear memory extinction. and, it blocked bdnf in the bla-induced enhancement of trkb phosphorylation in the infralimbic prefrontal cortex (il). together, this study not only suggests that pre-synaptic trkb in bla neurons is necessary for memory extinction and contributes to the bdnf signaling transduction from the bla to il, but also provides cc1-egfp as a novel tool to specifically regulate pre-synaptic trkb expression in vitro and in vivo. |
| WOS关键词 | ACTIVATED PROTEIN-KINASE ; NEUROTROPHIC FACTOR ; FEAR EXTINCTION ; SYNAPTIC-TRANSMISSION ; ANTEROGRADE TRANSPORT ; PREFRONTAL CORTEX ; DENDRITIC SPINE ; CIRCUITS ; RECEPTOR ; EXPRESSION |
| WOS研究方向 | Cell Biology |
| WOS类目 | Cell Biology |
| 语种 | 英语 |
| 出版者 | NATURE PUBLISHING GROUP |
| WOS记录号 | WOS:000406870400048 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2176949 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Su, Bo; Sun, Tao |
| 作者单位 | 1.Shandong Univ, Qilu Hosp, Shandong Prov Key Lab Immunohematol, 107 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China 2.Shandong Univ, Sch Med, Shandong Prov Key Lab Mental Disorders, Dept Neurobiol, Jinan 250012, Shandong, Peoples R China 3.Shandong Univ, Sch Med, Dept Immunol, Jinan 250012, Shandong, Peoples R China 4.Shandong Univ, Sch Life Sci, Jinan 250012, Shandong, Peoples R China 5.Chinese Acad Sci, Natl Ctr Nanosci & Technol, Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yuan,Wang, Dongdong,Li, Yang,et al. Pre-synaptic trkb in basolateral amygdala neurons mediates bdnf signaling transmission in memory extinction[J]. Cell death & disease,2017,8:11. |
| APA | Li, Yuan.,Wang, Dongdong.,Li, Yang.,Chu, Hongxia.,Zhang, Lining.,...&Sun, Tao.(2017).Pre-synaptic trkb in basolateral amygdala neurons mediates bdnf signaling transmission in memory extinction.Cell death & disease,8,11. |
| MLA | Li, Yuan,et al."Pre-synaptic trkb in basolateral amygdala neurons mediates bdnf signaling transmission in memory extinction".Cell death & disease 8(2017):11. |
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