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	Apoptosis induced by nayf4:eu3+ nanoparticles in liver cells via mitochondria damage dependent pathway
	Zhang, Shaohan1; Chen, Shizhu1; Gao, Chunyue1; Jin, Yi1; Jia, Guang1; Li, Zhenhua1; Liu, Dandan1; Liang, Xingjie2; Yang, Xinjian1; Zhang, Jinchao1
刊名	Science china-chemistry
	2017
卷号	60期号:1页码:122-129
关键词	Nayf4 nanoparticles Liver cells Apoptosis Oxidative stress Mitochondria damage
ISSN号	1674-7291
DOI	10.1007/s11426-016-0225-5
通讯作者	Yang, xinjian(jianxinyang123@163.com) ; Zhang, jinchao(jczhang6970@163.com)
英文摘要	As lanthanide-doped sodium yttrium flouride (nayf4) nanoparticles have great potential in biomedical applications, their biosafety is important and has attracted significant attention. in the present work, three different sized nayf4:eu3+ nanoparticles have been prepared. liver brl 3a cell was used as a cell model to evaluate their biological effects. cell viability and apoptosis assays were used to confirm the cytotoxicity induced by nayf4:eu3+ nps. apart from the elevated malondialdehyde (mda), the decrease of superoxide dismutase (sod), glutathione peroxidase (gsh-px) and catalase (cat) activity indicated reactive oxygen species (ros) generation, which were associated with oxidative damage. the decrease of mitochondrial membrane potential (mmp) value demonstrated the occurrence of mitochondria damage. then, release of cytochrome c from mitochondria and activation of caspase-3 confirmed that nayf4:eu3+ nps induced apoptosis was mitochondria damage-dependent.
WOS关键词	LANTHANIDE-DOPED NANOPARTICLES ; CERIUM OXIDE NANOPARTICLES ; OXIDATIVE STRESS ; CYTOCHROME-C ; UPCONVERTING NANOCRYSTALS ; CYTOTOXICITY ; SIZE ; BIODISTRIBUTION ; INDUCTION ; AUTOPHAGY
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
语种	英语
出版者	SCIENCE PRESS
WOS记录号	WOS:000392085900014
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2176851
专题	高能物理研究所
通讯作者	Yang, Xinjian; Zhang, Jinchao
作者单位	1.Hebei Univ, Coll Chem & Environm Sci, Key Lab Med Chem & Mol Diag, Minist Educ,Chem Biol Key Lab Hebei Prov, Baoding 071002, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Shaohan,Chen, Shizhu,Gao, Chunyue,et al. Apoptosis induced by nayf4:eu3+ nanoparticles in liver cells via mitochondria damage dependent pathway[J]. Science china-chemistry,2017,60(1):122-129.
APA	Zhang, Shaohan.,Chen, Shizhu.,Gao, Chunyue.,Jin, Yi.,Jia, Guang.,...&Zhang, Jinchao.(2017).Apoptosis induced by nayf4:eu3+ nanoparticles in liver cells via mitochondria damage dependent pathway.Science china-chemistry,60(1),122-129.
MLA	Zhang, Shaohan,et al."Apoptosis induced by nayf4:eu3+ nanoparticles in liver cells via mitochondria damage dependent pathway".Science china-chemistry 60.1(2017):122-129.

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