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	Two-step assembling of near-infrared "off-on" fluorescent nanohybrids for synchronous tumor imaging and microrna modulation-based therapy
	Deng, Xiongwei1,2; Yin, Zhaoxia1; Lu, Jianqing2; Xia, Yang1; Shao, Leihou2; Hu, Qin1; Zhou, Zhixiang1; Zhang, Fang1; Zhou, Shaomei1; Wu, Yan2
刊名	Acs applied materials & interfaces
	2017-02-01
卷号	9期号:4页码:3294-3305
关键词	Nanohybrids Nir fluorescence "off-on" Tumor imaging Microrna modulation therapy
ISSN号	1944-8244
DOI	10.1021/acsami.6b11438
通讯作者	Wu, yan(wuy@nanoctr.cn) ; Sheng, wang(shengwang@bjut.edu.cn)
英文摘要	Theranostic nanoparticles with combined imaging and therapy functions show great promise in cancer precision medicine. in this study, we constructed near-infrared (nir) "off-on" fluorescent nanohybrids (f-pnds) for synchronous tumor imaging and microrna (mirna) modulation therapy against esophageal cancer. nanodiamond clusters (nds) were first functionalized for protamine sulfate immobilization (pnds) on their surfaces via a noncovalent self-assembling approach and simultaneous encapsulation of nir emitting fluorescence dye cyanine 5 (cy-5) (f-pnds). tumor suppressor mirna-203 (mir-203) was then adsorbed onto the surface of f-pnds to form mir-203/f-pnds via electrostatic interactions. the size, morphology, photophysical and stability properties of mir-203/f-pnds were analyzed. we found that the nir fluorescence of mir-203/f-pnds could be activated to the "on" state in intracellular environment while remaining in the "off" state in extracellular or blood environment. furthermore, in vivo live imaging experiments showed that mir-203/f-pnds could be predominantly accumulated in tumor tissues and image the tumor sites 24 h postintravenous injection. in addition, intravenous and intratumoral injection of mir-203/f-pnds could efficiently inhibit tumor growth through down-regulation of the expressions of oncogenes ran and delta p63. our study indicated that mirna/f-pnds could serve as a promising theranostic platform for synchronous tumor imaging and mirna-based modulation therapy against cancer.
WOS关键词	NEGATIVE BREAST-CANCER ; DRUG-DELIVERY ; IN-VIVO ; THERANOSTIC NANOPARTICLES ; GENE DELIVERY ; QUANTUM DOTS ; NANODIAMONDS ; CELLS ; RELEASE ; AGENTS
WOS研究方向	Science & Technology - Other Topics ; Materials Science
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000393355900011
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2176829
专题	高能物理研究所
通讯作者	Wu, Yan; Sheng, Wang
作者单位	1.Beijing Univ Technol, Coll Life Sci & Bioengn, 100 Pingleyuan, Beijing 100124, Peoples R China 2.CAS Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, 11 Beiyitiao, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Deng, Xiongwei,Yin, Zhaoxia,Lu, Jianqing,et al. Two-step assembling of near-infrared "off-on" fluorescent nanohybrids for synchronous tumor imaging and microrna modulation-based therapy[J]. Acs applied materials & interfaces,2017,9(4):3294-3305.
APA	Deng, Xiongwei.,Yin, Zhaoxia.,Lu, Jianqing.,Xia, Yang.,Shao, Leihou.,...&Zeng, Yi.(2017).Two-step assembling of near-infrared "off-on" fluorescent nanohybrids for synchronous tumor imaging and microrna modulation-based therapy.Acs applied materials & interfaces,9(4),3294-3305.
MLA	Deng, Xiongwei,et al."Two-step assembling of near-infrared "off-on" fluorescent nanohybrids for synchronous tumor imaging and microrna modulation-based therapy".Acs applied materials & interfaces 9.4(2017):3294-3305.

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