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	Near-infrared emission cuins/zns quantum dots: all-in-one theranostic nanomedicines with intrinsic fluorescence/photoacoustic imaging for tumor phototherapy
	Lv, Guoxian1,2,3,4; Guo, Weisheng2,3,4; Zhang, Wei2,3,4; Zhang, Tingbin2,3,4; Li, Shuyi2,3,4; Chen, Shizhu5; Eltahan, Ahmed Shaker2,3,4; Wang, Dongliang2,3,4; Wang, Yuqing2,3,4; Zhang, Jinchao5
刊名	Acs nano
	2016-10-01
卷号	10期号:10页码:9637-9645
关键词	Cuins/zns quantum dots Photoacoustic imaging Multispectral optical tomography Photothermal therapy Photodynamic therapy
ISSN号	1936-0851
DOI	10.1021/acsnano.6b05419
通讯作者	Guo, weisheng(guows@nanoctr.cn) ; Chang, jin(jinchang@tju.edu.cn) ; Liang, xing-jie(liangxj@nanoctr.cn)
英文摘要	Many theranostic nanomedicines (nms) have been fabricated by packaging imaging and therapeutic moieties together. however, concerns about their potential architecture instability and pharmacokinetic complexity remain major obstacles to their clinical translation. herein, we demonstrated the use of cuins/zns quantum dots (zcis qds) as "all-in-one" theranostic nanomedicines that possess intrinsic imaging and therapeutic capabilities within a well-defined nanostructure. zcis qds were exploited for multispectral optical tomography (msot) imaging and synergistic ptt/pdt therapy. due to the intrinsic zcis qds fluorescence/msot imaging ability of the zcis qds, their size-dependent distribution profiles were successfully visualized at tumor sites in vivo. our results showed that the smaller nanomedicines (zcis nms-25) have longer tumor retention times, higher tumor uptake, and deeper tumor penetration than the larger nanomedicines (zcis nms-80). the ability of zcis qds to mediate photoinduced tumor ablation was also explored. our results verified that under a single 660 nm laser irradiation, the zcis nms had simultaneous inherent photothermal and photodynamic effects, resulting in high therapy efficacy against tumors. in summary, the zcis qds as "all-in-one" versatile nanomedicines allow high therapeutic efficacy as well as noninvasively monitoring tumor site localization profiles by imaging techniques and thus hold great potential as precision theranostic nanomedicines.
WOS关键词	GOLD NANOROD VESICLES ; PHOTODYNAMIC THERAPY ; CANCER-THERAPY ; DRUG-DELIVERY ; LIVING MICE ; NANOPARTICLES ; SMART ; NANOCRYSTALS ; PENETRATION ; ORGANELLES
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000386423600066
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2176647
专题	高能物理研究所
通讯作者	Guo, Weisheng; Chang, Jin; Liang, Xing-Jie
作者单位	1.Tianjin Univ, Tianjin Engn Ctr Micronano Biomat & Detect Treatm, Sch Life Sci, Sch Mat Sci & Engn, Tianjin 300072, Peoples R China 2.Chinese Acad Sci, Ctr Excellence Nanosci, Lab Controllable Nanopharmaceut, Beijing 100190, Peoples R China 3.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Hebei Univ, Coll Chem & Environm Sci, Chem Biol Key Lab Hebei Prov, Key Lab Med Chem & Mol Diag,Minist Educ, Baoding 071002, Peoples R China 6.Howard Univ, Dept Radiol, Lab Mol Imaging, Washington, DC 20060 USA
推荐引用方式 GB/T 7714	Lv, Guoxian,Guo, Weisheng,Zhang, Wei,et al. Near-infrared emission cuins/zns quantum dots: all-in-one theranostic nanomedicines with intrinsic fluorescence/photoacoustic imaging for tumor phototherapy[J]. Acs nano,2016,10(10):9637-9645.
APA	Lv, Guoxian.,Guo, Weisheng.,Zhang, Wei.,Zhang, Tingbin.,Li, Shuyi.,...&Liang, Xing-Jie.(2016).Near-infrared emission cuins/zns quantum dots: all-in-one theranostic nanomedicines with intrinsic fluorescence/photoacoustic imaging for tumor phototherapy.Acs nano,10(10),9637-9645.
MLA	Lv, Guoxian,et al."Near-infrared emission cuins/zns quantum dots: all-in-one theranostic nanomedicines with intrinsic fluorescence/photoacoustic imaging for tumor phototherapy".Acs nano 10.10(2016):9637-9645.

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