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	Oxidation and temperature dual responsive polymers based on phenylboronic acid and n-isopropylacrylamide motifs
	Zhang, Mei1; Song, Cheng-Cheng1; Ji, Ran1; Qiao, Zeng-Ying2; Yang, Chao2; Qiu, Fang-Yi1; Liang, De-Hai1; Du, Fu-Sheng1; Li, Zi-Chen1
刊名	Polymer chemistry
	2016
卷号	7期号:7页码:1494-1504
ISSN号	1759-9954
DOI	10.1039/c5py01999k
通讯作者	Du, fu-sheng(fsdu@pku.edu.cn) ; Li, zi-chen(zcli@pku.edu.cn)
英文摘要	Oxidation stress has been becoming an important target for the development of smart nanomedicines, triggering research interest in oxidation responsive polymers. herein, we report a new type of temperature/ oxidation dual responsive copolymer. they were synthesized by the sequential atom transfer radical copolymerization (atrp) of n-isopropylacrylamide (nipam, m1) and a phenylboronic pinacol estercontaining acrylate (m2) and dialysis against water to remove the pinacol protecting groups. the copolymers with a small amount of phenylboronic acid units (< 7%) were soluble in cold neutral phosphate buffer but showed lower critical solution temperatures in the range of 12-31 degrees c. the thermally induced phase transition profiles depended on both the composition and concentration of the polymers. the cloud points of the copolymers were shifted to higher temperatures upon h2o2 induced oxidation of the phenylboronic acid and the subsequent 1,6-elimination. using peg-cl as the macroinitiator to initiate atrp of m1 and m2, three block copolymers composed of a peg block and a temperature/oxidation dual responsive segment were prepared after dialysis in water. these block copolymers had a similar ratio of nipam to phenylboronic acid units but different molecular weights. we have studied their thermal selfassembly and h2o2 triggered decomposition by laser light scattering, h-1 nmr, and transmission electron microscopy. upon a fast heating protocol, these block copolymers formed stable micelle-like nanoparticles (at 37 degrees c) that were capable of encapsulating doxorubicin (dox) and showed h2o2 triggered release. the naked nanoparticles were cytocompatible, however the dox-loaded ones exhibited concentration dependent cytotoxicity, in particular to cancer cells.
WOS关键词	CYCLIC ORTHOESTER GROUPS ; REACTIVE OXYGEN ; DRUG-DELIVERY ; BLOCK-COPOLYMERS ; POLY(ETHYLENE GLYCOL) ; HYDROGEN-PEROXIDE ; BIOMEDICAL APPLICATIONS ; AQUEOUS-SOLUTIONS ; POLY(N-ISOPROPYLACRYLAMIDE) ; NANOPARTICLES
WOS研究方向	Polymer Science
WOS类目	Polymer Science
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000369692700016
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2176573
专题	高能物理研究所
通讯作者	Du, Fu-Sheng; Li, Zi-Chen
作者单位	1.Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Polymer Chem & Phys,Minist Educ, Ctr Soft Matter Sci & Engn,Coll Chem & Mol Engn, Beijing 100871, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Mei,Song, Cheng-Cheng,Ji, Ran,et al. Oxidation and temperature dual responsive polymers based on phenylboronic acid and n-isopropylacrylamide motifs[J]. Polymer chemistry,2016,7(7):1494-1504.
APA	Zhang, Mei.,Song, Cheng-Cheng.,Ji, Ran.,Qiao, Zeng-Ying.,Yang, Chao.,...&Li, Zi-Chen.(2016).Oxidation and temperature dual responsive polymers based on phenylboronic acid and n-isopropylacrylamide motifs.Polymer chemistry,7(7),1494-1504.
MLA	Zhang, Mei,et al."Oxidation and temperature dual responsive polymers based on phenylboronic acid and n-isopropylacrylamide motifs".Polymer chemistry 7.7(2016):1494-1504.

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