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	Acidic ph-induced charge-reversal nanoparticles for accelerated endosomal escape and enhanced microrna modulation in cancer cells
	Deng, Xiongwei1,2; Wang, Yihui1; Zhang, Fang1; Yin, Zhaoxia1; Hu, Qin1; Xiao, Xiangqian1; Zhou, Zhixiang1; Wu, Yan2; Sheng, Wang1; Zeng, Yi1
刊名	Chemical communications
	2016
卷号	52期号:15页码:3243-3246
ISSN号	1359-7345
DOI	10.1039/c5cc10396g
通讯作者	Wu, yan(wuy@nanoctr.cn) ; Sheng, wang(shengwang@bjut.edu.cn)
英文摘要	Ph-induced charge-reversal nanoparticles incorporating microrna (mirna) were engineered through a single-step self-assembly of polyelectrolyte complexes. we found that the endosomal/lysosomal acidic environment could trigger the charge reversal of the nanoparticles from negative charge to positive charge and induce the structure alteration of the nanoparticles, which in turn led to accelerated endosomal escape and enhanced mirna modulation in esophageal cancer cells.
WOS关键词	DRUG-DELIVERY ; HYBRID NANOPARTICLES ; SIRNA DELIVERY ; EXPRESSION ; TUMOR
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000370573400039
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2176564
专题	高能物理研究所
通讯作者	Wu, Yan; Sheng, Wang
作者单位	1.Beijing Univ Technol, Coll Life Sci & Bioengn, 100 Pingleyuan, Beijing 100124, Peoples R China 2.Chinese Acad Sci, Key Lab Biol Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol, 11 First North Rd, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Deng, Xiongwei,Wang, Yihui,Zhang, Fang,et al. Acidic ph-induced charge-reversal nanoparticles for accelerated endosomal escape and enhanced microrna modulation in cancer cells[J]. Chemical communications,2016,52(15):3243-3246.
APA	Deng, Xiongwei.,Wang, Yihui.,Zhang, Fang.,Yin, Zhaoxia.,Hu, Qin.,...&Zeng, Yi.(2016).Acidic ph-induced charge-reversal nanoparticles for accelerated endosomal escape and enhanced microrna modulation in cancer cells.Chemical communications,52(15),3243-3246.
MLA	Deng, Xiongwei,et al."Acidic ph-induced charge-reversal nanoparticles for accelerated endosomal escape and enhanced microrna modulation in cancer cells".Chemical communications 52.15(2016):3243-3246.

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