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	Combination therapy using co-encapsulated resveratrol and paclitaxel in liposomes for drug resistance reversal in breast cancer cells in vivo
	Meng, Jie1; Guo, Fangqin2; Xu, Haiyan3,4; Liang, Wei5; Wang, Chen1; Yang, Xian-Da3,4
刊名	Scientific reports
	2016-03-07
卷号	6页码:11
ISSN号	2045-2322
DOI	10.1038/srep22390
通讯作者	Wang, chen(wangch@nanoctr.cn) ; Yang, xian-da(ayangmd@gmail.com)
英文摘要	Multidrug resistance (mdr) is a major impediment to cancer treatment. a promising strategy for treating mdr is the joint delivery of combined anticancer agents to tumor cells in a single nanocarrier. here, for the first time, resveratrol (res) was co-encapsulated with paclitaxel (ptx) in a pegylated liposome to construct a carrier-delivered form of combination therapy for drug-resistant tumors. the composite liposome had an average diameter of 50 nm with encapsulated efficiencies of above 50%. the studies demonstrated that the composite liposome could generate potent cytotoxicity against the drug-resistant mcf-7/adr tumor cells in vitro and enhance the bioavailability and the tumor-retention of the drugs in vivo. moreover, systemic therapy with the composite liposome effectively inhibited drug-resistant tumor in mice (p < 0.01), without any notable increase in the toxicity. these results suggested that the co-delivery of res and a cytotoxic agent in a nanocarrier may potentially improve the treatment of drug-resistant tumors.
WOS关键词	MULTIDRUG-RESISTANCE ; TRIGGERS APOPTOSIS ; CYCLOSPORINE-A ; CHEMOTHERAPY ; NANOPARTICLES ; TRANSPORTERS ; DOXORUBICIN ; MECHANISMS
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000371405100001
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2176542
专题	高能物理研究所
通讯作者	Wang, Chen; Yang, Xian-Da
作者单位	1.Natl Ctr Nanosci & Technol China, Key Lab Biol Effects Nanomat & Nanosafety, Beijing, Peoples R China 2.S China Normal Univ, Guangzhou, Guangdong, Peoples R China 3.Chinese Acad Med Sci, Inst Basic Med Sci, Beijing 100730, Peoples R China 4.Peking Union Coll, Beijing, Peoples R China 5.Inst Biophys, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Meng, Jie,Guo, Fangqin,Xu, Haiyan,et al. Combination therapy using co-encapsulated resveratrol and paclitaxel in liposomes for drug resistance reversal in breast cancer cells in vivo[J]. Scientific reports,2016,6:11.
APA	Meng, Jie,Guo, Fangqin,Xu, Haiyan,Liang, Wei,Wang, Chen,&Yang, Xian-Da.(2016).Combination therapy using co-encapsulated resveratrol and paclitaxel in liposomes for drug resistance reversal in breast cancer cells in vivo.Scientific reports,6,11.
MLA	Meng, Jie,et al."Combination therapy using co-encapsulated resveratrol and paclitaxel in liposomes for drug resistance reversal in breast cancer cells in vivo".Scientific reports 6(2016):11.

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