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	Synthesis and self-assembly of ph and ros dual responsive poly(beta-thioester)s
	Zhao Wenjing1; Qiao Zengying2; Duan Zhongyu1; Wang Hao2
刊名	Acta chimica sinica
	2016-03-15
卷号	74期号:3页码:234-240
关键词	Poly(beta-thioester)s Nanoparticles Ph-responsive Ros-responsive Self-assembly
ISSN号	0567-7351
DOI	10.6023/a15120787
通讯作者	Duan zhongyu(zyduan@hebut.edu.cn) ; Wang hao(wanghao@nanoctr.cn)
英文摘要	The michael addition reaction, which is a mild reaction between activated olefins and nucleophiles, has been widely used in synthesis of tailored macromolecular architectures. we designed a copolymer nanoparticle to obtain the ros and ph dual responsive capability. we synthesized the amphiphilic poly(beta-thioester)s copolymers (d-d-p) composed of di(ethylene glycol) diacrylate (deda), dl-dithiothreitol (dtt), acryloyl chloride (ac) and hydrophilic peg-sh with average m-n= 2000 g.mol(-1) via michael addition reaction. the reactions are facile and controllable, and the structures of acquired copolymers are well characterized. the structures of the polymers were confirmed by h-1 nmr, and the number molecular weight and distribution of the copolymer d-d-p was measured by gpc (m-n= 50400). d-d-p could self-assemble into nano particles with core-shell structures by dialysis method due to the composition of hydrophilic side chains and hydrophobic polymer backbones. after the preparation of ros and ph dual responsive d-d-p nanoparticles in phosphate buffer solution, the morphology and size of d-d-p nanoparticles were observed by transmission electron microscopy (tem) and dynamic light scattering (dls) showed that the number size distribution of nanoparticles was around 280 nm. nile red (nr) is a unique neutral hydrophobic molecule, which shows very weak fluorescence in aqueous solution and can emit strong fluorescence in the hydrophobic environment. nr absorption and emission spectra are strongly dependent on environment polarity, which make it as a probe molecule that is widely used in the evaluation of microenvironment polarity. the disassembly behaviors of d-d-p nanoparticles were investigated by the change of the nanoparticle size and nr fluorescence spectra. the diameter of nanoparticle decreased under ph 5 and ros environment conditions, and the nr fluorescence also became weak under ph 5 and ros environment conditions, which could be attributed to the gradual dissociation of nanoparticles, proving the ros and ph dual responsive properties of the poly(beta-thioester)s. the release behaviors of the dox encapsulated d-d-p nanoparticles in acidic and oxidative condition were studied by the uv absorption and were further proved in mcf-7 cells.
WOS关键词	DRUG-DELIVERY ; BIOMEDICAL APPLICATIONS ; POLYMERIC MICELLES ; CANCER ; RELEASE ; HYDROGELS ; EXPLOITATION ; NANOPARTICLE ; COPOLYMERS ; TUMOR
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
语种	英语
出版者	SCIENCE PRESS
WOS记录号	WOS:000373751500002
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2176521
专题	高能物理研究所
通讯作者	Duan Zhongyu; Wang Hao
作者单位	1.Hebei Univ Technol, Sch Chem Engn, Tianjin 300130, Peoples R China 2.Natl Ctr Nanosci & Technol NCNST, CAS Key Lab Biol Effects Nanomat & Nanosafety, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Zhao Wenjing,Qiao Zengying,Duan Zhongyu,et al. Synthesis and self-assembly of ph and ros dual responsive poly(beta-thioester)s[J]. Acta chimica sinica,2016,74(3):234-240.
APA	Zhao Wenjing,Qiao Zengying,Duan Zhongyu,&Wang Hao.(2016).Synthesis and self-assembly of ph and ros dual responsive poly(beta-thioester)s.Acta chimica sinica,74(3),234-240.
MLA	Zhao Wenjing,et al."Synthesis and self-assembly of ph and ros dual responsive poly(beta-thioester)s".Acta chimica sinica 74.3(2016):234-240.

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