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	Facile synthesis of gd-cu-in-s/zns bimodal quantum dots with optimized properties for tumor targeted fluorescence/mr in vivo imaging
	Yang, Weitao1; Guo, Weisheng3; Gong, Xiaoqun1; Zhang, Bingbo2; Wang, Sheng1; Chen, Na4; Yang, Wentao1; Tu, Yu4; Fang, Xiangming5; Chang, Jin1
刊名	Acs applied materials & interfaces
	2015-08-26
卷号	7期号:33页码:18759-18768
关键词	Quantum dots Mri Targeted imaging Dual-modal imaging Fluorescence imaging
ISSN号	1944-8244
DOI	10.1021/acsami.5b05372
通讯作者	Zhang, bingbo(bingbozhang@tongji.edu.cn)
英文摘要	Dual-modal imaging techniques have gained intense attention for their potential role in the dawning era of tumor early accurate diagnosis. chelate-free robust dual-modal imaging nanoprobes with high efficiency and low toxicity are of essential importance for tumor targeted dual-modal in vivo imaging. it is still a crucial issue to endow cd-free dual-modal nanoprobes with bright fluorescence as well as high relaxivity. herein, a facile synthetic strategy was developed to prepare gd-doped cuins/zns bimodal quantum dots (gcis/zns, bqds) with optimized properties. the fluorescent properties of the gcis/zns bqds can be thoroughly optimized by varying reaction temperature, aging time, and zns coating. the amount of gd precursor can be well-controlled to realize the optimized balance between the mr relaxivity and optical properties. the obtained hydrophobic gcis/zns bqds were surface engineered into aqueous phase with pegylated dextran-stearyl acid polymeric lipid vesicles (peg-ds plvs). upon the phase transfer, the hydrophilic gcis/zns@plvs exhibited pronounced near-infrared fluorescence as well as high longitudinal relaxivity (r(1)= 9.45 mm(-1) s-1) in water with good colloidal stability. in vivo tumor-bearing animal experiments further verified gcis/zns@plvs could achieve tumor-targeted mr/fluorescence dual-modal imaging. no toxicity was observed in the in vivo and ex vivo experiments. the gcis/zns@plvs present great potential as bimodal imaging contrast agents for tumor diagnosis.
WOS关键词	MRI CONTRAST AGENTS ; MAGNETIC-RESONANCE ; SEMICONDUCTOR NANOCRYSTALS ; NANOPARTICLES ; PHOTOLUMINESCENCE ; PROBES ; ELECTROLUMINESCENCE ; LUMINESCENCE ; NANOCLUSTERS ; PERFORMANCE
WOS研究方向	Science & Technology - Other Topics ; Materials Science
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000360322000067
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2176410
专题	高能物理研究所
通讯作者	Zhang, Bingbo
作者单位	1.Tianjin Univ, Collaborat Innovat Ctr Chem Sci & Engn, Tianjin Engn Ctr Micronano Biomat & Detect Treatm, Sch Mat Sci & Engn,Sch Life Sci, Tianjin 300072, Peoples R China 2.Tongji Univ, Shanghai East Hosp, Inst Biomed Engn & Nano Sci, Sch Med, Shanghai 200092, Peoples R China 3.Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 4.Soochow Univ, Sch Radiat Med & Hlth, Dept Med Radioprotect, Suzhou 200072, Peoples R China 5.Nanjing Med Univ, Wuxi Peoples Hosp, Dept Radiol, Nanjing 214023, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Yang, Weitao,Guo, Weisheng,Gong, Xiaoqun,et al. Facile synthesis of gd-cu-in-s/zns bimodal quantum dots with optimized properties for tumor targeted fluorescence/mr in vivo imaging[J]. Acs applied materials & interfaces,2015,7(33):18759-18768.
APA	Yang, Weitao.,Guo, Weisheng.,Gong, Xiaoqun.,Zhang, Bingbo.,Wang, Sheng.,...&Chang, Jin.(2015).Facile synthesis of gd-cu-in-s/zns bimodal quantum dots with optimized properties for tumor targeted fluorescence/mr in vivo imaging.Acs applied materials & interfaces,7(33),18759-18768.
MLA	Yang, Weitao,et al."Facile synthesis of gd-cu-in-s/zns bimodal quantum dots with optimized properties for tumor targeted fluorescence/mr in vivo imaging".Acs applied materials & interfaces 7.33(2015):18759-18768.

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