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	Intrinsic noise and hill dynamics in the p53 system
	Liu, Bo1; Yan, Shiwei1,2,3; Wang, Qi1
刊名	Journal of theoretical biology
	2011-01-21
卷号	269期号:1页码:104-108
关键词	Protein circuit Modeling Noise Nonlinear analysis
ISSN号	0022-5193
DOI	10.1016/j.jtbi.2010.10.009
通讯作者	Yan, shiwei(yansw@bnu.edu.cn)
英文摘要	The p53 feedback loop can induce cellular senescence, cell cycle arrest and apoptosis in response to various stresses, including dna damage, hypoxia and nutrient deprivation. using a stochastic model of the negative feedback circuit involving p53 and its inhibitor mdm2, we present the different oscillatory dynamics at the single-cell and population-cell levels as described in the experiments, and the resonant nature of the oscillations is captured. the stationary distributions of protein populations are characterized by non-gaussian nature which is due to the interplay between time delay and nonlinearity of reactions. (c) 2010 elsevier ltd. all rights reserved.
WOS关键词	P53-MDM2 FEEDBACK LOOP ; DNA-DAMAGE ; OSCILLATIONS ; MODEL ; NETWORK ; PULSES ; CELLS ; MDM2 ; BISTABILITY ; SIMULATION
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Mathematical & Computational Biology
WOS类目	Biology ; Mathematical & Computational Biology
语种	英语
出版者	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
WOS记录号	WOS:000286173000011
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2176213
专题	高能物理研究所
通讯作者	Yan, Shiwei
作者单位	1.Beijing Normal Univ, Coll Nucl Sci & Technol, Beijing 100875, Peoples R China 2.Beijing Radiat Ctr, Beijing 100875, Peoples R China 3.Ctr Theoret Phys, Natl Lab Heavy Ion Accelerator Lanzhou, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Liu, Bo,Yan, Shiwei,Wang, Qi. Intrinsic noise and hill dynamics in the p53 system[J]. Journal of theoretical biology,2011,269(1):104-108.
APA	Liu, Bo,Yan, Shiwei,&Wang, Qi.(2011).Intrinsic noise and hill dynamics in the p53 system.Journal of theoretical biology,269(1),104-108.
MLA	Liu, Bo,et al."Intrinsic noise and hill dynamics in the p53 system".Journal of theoretical biology 269.1(2011):104-108.

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