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	Copper ions influence the toxicity of beta-amyloid(1-42) in a concentration-dependent manner in a caenorhabditis elegans model of alzheimer's disease
	Luo YunFeng1,2; Zhang Jie3; Liu NianQing4; Luo Yuan5; Zhao BaoLu1
刊名	Science china-life sciences
	2011-06-01
卷号	54期号:6页码:527-534
关键词	Alzheimer's disease Beta-amyloid(1-42) Copper C. elegans Oxidative stress
ISSN号	1674-7305
DOI	10.1007/s11427-011-4180-z
通讯作者	Zhao baolu(zhaobl@sun5.ibp.ac.cn)
英文摘要	Beta-amyloid (a beta) and copper play important roles in the pathogenesis of alzheimer's disease (ad). however, the behavioral correlativity and molecular mechanisms of a beta and copper toxicity have been investigated less often. in the present study, we investigated the interaction and toxicity of a beta 1-42 and copper in the a beta 1-42 transgenic caenorhabditis elegans worm model cl2006. our data show that the paralysis behavior of cl2006 worms significantly deteriorated after exposure to 10(-3) mol l(-1) copper ions. however, the paralysis behavior was dramatically attenuated with exposure to 10(-4) mol l(-1) copper ions. the exogenous copper treatment also partially changed the homeostatic balance of zinc, manganese, and iron. our data suggest that the accumulation of reactive oxygen species (ros) was responsible for the paralysis induced by a beta and copper in cl2006. the ros generation induced by a beta and copper appear to be through sod-1, prdx-2, skn-1, hsp-60 and hsp-16.2 genes.
WOS关键词	OXIDATIVE STRESS HYPOTHESIS ; C-ELEGANS ; NEURODEGENERATIVE DISEASES ; GENE-EXPRESSION ; LIFE-SPAN ; BETA ; PROTEOTOXICITY ; REDUCTION ; MECHANISM ; PLAQUES
WOS研究方向	Life Sciences & Biomedicine - Other Topics
WOS类目	Biology
语种	英语
出版者	SCIENCE CHINA PRESS
WOS记录号	WOS:000292050500005
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2176115
专题	高能物理研究所
通讯作者	Zhao BaoLu
作者单位	1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Rutgers State Univ, Dept Cell Biol, Piscataway, NJ 08854 USA 4.Chinese Acad Sci, Inst High Energy Phys, Synchrotron Radiat Lab, Beijing 100049, Peoples R China 5.Univ Maryland, Dept Pharmaceut Sci, Baltimore, MD 21201 USA
推荐引用方式 GB/T 7714	Luo YunFeng,Zhang Jie,Liu NianQing,et al. Copper ions influence the toxicity of beta-amyloid(1-42) in a concentration-dependent manner in a caenorhabditis elegans model of alzheimer's disease[J]. Science china-life sciences,2011,54(6):527-534.
APA	Luo YunFeng,Zhang Jie,Liu NianQing,Luo Yuan,&Zhao BaoLu.(2011).Copper ions influence the toxicity of beta-amyloid(1-42) in a concentration-dependent manner in a caenorhabditis elegans model of alzheimer's disease.Science china-life sciences,54(6),527-534.
MLA	Luo YunFeng,et al."Copper ions influence the toxicity of beta-amyloid(1-42) in a concentration-dependent manner in a caenorhabditis elegans model of alzheimer's disease".Science china-life sciences 54.6(2011):527-534.

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