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	Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy peg-plga copolymer nanoparticles
	Wang, Hai1; Zhao, Ying1; Wu, Yan1; Hu, Yu-lin2; Nan, Kaihui3; Nie, Guangjun1; Chen, Hao3
刊名	Biomaterials
	2011-11-01
卷号	32期号:32页码:8281-8290
关键词	Nanotechnology Co-delivery of drugs Multifunctional nanoparticles Double emulsion Controlled drug release
ISSN号	0142-9612
DOI	10.1016/j.biomaterials.2011.07.032
通讯作者	Nie, guangjun(niegj@nanoctr.cn)
英文摘要	The use of single chemotherapeutic drug has shown some limitations in anti-tumor treatment, such as development of drug resistance, high toxicity and limited regime of clinical uses. the combination of two or more therapeutic drugs is feasible means to overcome the limitations. co-delivery strategy has been proposed to minimize the amount of each drug and to achieve the synergistic effect for cancer therapies. attempts have been made to deliver chemotherapeutic drugs simultaneously using drug carriers, such as micelles, liposomes, and inorganic nanoparticles (nps). here we reported core-shell nps that were doubly emulsified from an amphiphilic copolymer methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) (mpeg-plga). these nps offered advantages over other nanocarriers, as they were easy to fabricate by improved double emulsion method, biocompatible, and showed high loading efficacy. more importantly, these nps could co-deliver hydrophilic doxorubicin (dox) and hydrophobic paclitaxel (tax). the drug-loaded nps possessed a better polydispersity, indicating that they are more readily subject to controlled size distribution. studies on drug release and cellular uptake of the co-delivery system demonstrated that both drugs were effectively taken up by the cells and released simultaneously. furthermore, the co-delivery nanocarrier suppressed tumor cells growth more efficiently than the delivery of either dox or tax at the same concentrations, indicating a synergistic effect. moreover, the nps loading drugs with a dox/tax concentration ratio of 2:1 showed the highest anti-tumor activity to three different types of tumor cells. this nanocarrier might have important potential in clinical implications for co-delivery of multiple anti-tumor drugs with different properties. (c) 2011 elsevier ltd. all rights reserved.
WOS关键词	MULTIDRUG-RESISTANT CANCER ; DOUBLE EMULSIONS ; MICELLAR NANOPARTICLES ; INDUCED APOPTOSIS ; DRUG-DELIVERY ; BREAST-CANCER ; CELL-DEATH ; TAXOL ; RELEASE ; ENCAPSULATION
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000295241200025
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2176083
专题	高能物理研究所
通讯作者	Nie, Guangjun
作者单位	1.Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Jilin Univ, Affiliated Hosp 1, Changchun 130021, Jilin Province, Peoples R China 3.Eye Hosp Wenzhou, Coll Med, Key Lab Ophthalmol & Optometry Zhejiang Prov, Wenzhou, Peoples R China
推荐引用方式 GB/T 7714	Wang, Hai,Zhao, Ying,Wu, Yan,et al. Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy peg-plga copolymer nanoparticles[J]. Biomaterials,2011,32(32):8281-8290.
APA	Wang, Hai.,Zhao, Ying.,Wu, Yan.,Hu, Yu-lin.,Nan, Kaihui.,...&Chen, Hao.(2011).Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy peg-plga copolymer nanoparticles.Biomaterials,32(32),8281-8290.
MLA	Wang, Hai,et al."Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy peg-plga copolymer nanoparticles".Biomaterials 32.32(2011):8281-8290.

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