| Polycationic nanoparticles as nonviral vectors employed for gene therapy in vivo | |
| Xing, Jinfeng1; Deng, Liandong1; Guo, Shutao1,2; Dong, Anjie1; Liang, Xing-Jie2 | |
| 刊名 | Mini-reviews in medicinal chemistry
 |
| 2010-02-01 | |
| 卷号 | 10期号:2页码:126-137 |
| 关键词 | Gene therapy Polycation Nanoparticles Non-viral vectors Transfection efficiency Pegylation Gene delivery Circulation time |
| ISSN号 | 1389-5575 |
| 通讯作者 | Dong, anjie(ajdong@tju.edu.cn) |
| 英文摘要 | Currently, polycationic nanoparticles (polycation) as nonviral vectors are promising to overcome the defects of traditional viral vectors. this review focuses on the recent progress and challenges to improve the transfection efficacy and circulation time of polyplexes (complexes between polycation and pdna or oligonucleotides such as sirna) in vivo. |
| WOS关键词 | LOW-MOLECULAR-WEIGHT ; POLYION COMPLEX MICELLES ; PLASMID DNA DELIVERY ; POLY(ETHYLENE GLYCOL)-BLOCK-POLYETHYLENIMINE COPOLYMERS ; HYPERBRANCHED POLY(AMINO ESTER)S ; DEGRADABLE POLYMER LIBRARY ; POLYETHYLENE-GLYCOL ; TRANSFECTION EFFICIENCY ; BLOCK-COPOLYMER ; LINEAR POLYETHYLENIMINE |
| WOS研究方向 | Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Medicinal |
| 语种 | 英语 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| WOS记录号 | WOS:000277156200003 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2175979 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Dong, Anjie |
| 作者单位 | 1.Tianjin Univ, Sch Chem Engn & Technol, Dept Polymer Sci & Engn, Tianjin 300072, Peoples R China 2.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Tianjin 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xing, Jinfeng,Deng, Liandong,Guo, Shutao,et al. Polycationic nanoparticles as nonviral vectors employed for gene therapy in vivo[J]. Mini-reviews in medicinal chemistry,2010,10(2):126-137. |
| APA | Xing, Jinfeng,Deng, Liandong,Guo, Shutao,Dong, Anjie,&Liang, Xing-Jie.(2010).Polycationic nanoparticles as nonviral vectors employed for gene therapy in vivo.Mini-reviews in medicinal chemistry,10(2),126-137. |
| MLA | Xing, Jinfeng,et al."Polycationic nanoparticles as nonviral vectors employed for gene therapy in vivo".Mini-reviews in medicinal chemistry 10.2(2010):126-137. |
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