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	Multi-center study on alzheimer's disease using fdg pet: group and individual analyses
	Yuan, Xiuli1; Shan, Baoci1; Ma, Yunchuan2; Tian, Jiahe3; Jiang, Kaida4; Cao, Qiuyun4; Wang, Ruimin3
刊名	Journal of alzheimers disease
	2010
卷号	19期号:3页码:927-935
关键词	Alzheimer's disease Hypo-metabolism Individual analysis Multicenter study Positron emission tomography
ISSN号	1387-2877
DOI	10.3233/jad-2010-1287
通讯作者	Shan, baoci(shanbc@ihep.ac.cn)
英文摘要	Using statistical parametric mapping (spm), we evaluate the feasibility and accuracy of (18)f-2-deoxy-2-fluoro-dglucose (fdg) positron emission tomography (pet) for clinical diagnosis with characteristic hypo-metabolic regions, and examine the consistency of cerebral hypo-metabolism in alzheimer's disease (ad) cross multicenters at both the group and the individual levels. four groups of scan data including 39 ad patients and 52 healthy control subjects derived from three centers were analyzed and comparisons between patient subgroups or individual patient and relevant control population were performed using two sample t-test. in the group analysis, the hypo-metabolic regions of ad patients obtained from different pet centers were similar and consistent. the common hypo-metabolic cerebral areas were located bilaterally in the posterior cingulate and medial parietal cortex, temporo-parietal cortex, prefrontal cortex, and the middle and inferior temporal gyrus (uncorrected, p < 0.001). in the analysis of each individual subject, the location of declined posterior cingulate and medial parietal cortex, temporo-parietal cortex and temporal lobe were found highly consistent with relevant characteristic regions obtained in the group analysis and were selected for diagnosic purposes. complete typical hypo-metabolic pattern was observed in 67% and 54% of ad patients in two sets of 3d scans, respectively. only 27% and 33.3% patients showed full typical pattern in two sets of 2d scans. the results indicated that fdg pet measures and spm can provide a valuable reference for clinical diagnosis of ad patients. the potential influence of acquisition mode on the clinical diagnosis of ad was suggested for further evaluation.
WOS关键词	POSITRON-EMISSION-TOMOGRAPHY ; MILD COGNITIVE IMPAIRMENT ; METABOLIC ABNORMALITIES ; GLUCOSE-METABOLISM ; DEMENTIA ; DIAGNOSIS ; DISCRIMINATION ; REDUCTION
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
语种	英语
出版者	IOS PRESS
WOS记录号	WOS:000276617100014
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2175969
专题	高能物理研究所
通讯作者	Shan, Baoci
作者单位	1.Chinese Acad Sci, Inst High Energy Phys, Beijing 100049, Peoples R China 2.Capital Univ Med Sci, Xuanwu Hosp, PET Ctr, Beijing, Peoples R China 3.Gen Hosp PLA, Dept Nucl Med, Beijing, Peoples R China 4.Mental Hlth Ctr Shanghai, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Yuan, Xiuli,Shan, Baoci,Ma, Yunchuan,et al. Multi-center study on alzheimer's disease using fdg pet: group and individual analyses[J]. Journal of alzheimers disease,2010,19(3):927-935.
APA	Yuan, Xiuli.,Shan, Baoci.,Ma, Yunchuan.,Tian, Jiahe.,Jiang, Kaida.,...&Wang, Ruimin.(2010).Multi-center study on alzheimer's disease using fdg pet: group and individual analyses.Journal of alzheimers disease,19(3),927-935.
MLA	Yuan, Xiuli,et al."Multi-center study on alzheimer's disease using fdg pet: group and individual analyses".Journal of alzheimers disease 19.3(2010):927-935.

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