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	Visual attention deficits in alzheimer's disease: an fmri study
	Hao, J; Li, KC; Li, K; Zhang, DX; Wang, W; Yang, YH; Yan, B; Shan, BC; Zhou, XL
刊名	Neuroscience letters
	2005-09-02
卷号	385期号:1页码:18-23
关键词	Functional mri Visual search Attention Alzheimer's disease
ISSN号	0304-3940
DOI	10.1016/j.neulet.2005.05.028
通讯作者	Li, kc()
英文摘要	Cognitive and neuroscience studies indicate that attentional operations are impaired in alzheimer's disease (ad). our goal was to define the anatomical areas of activation associated with visual attention processing and to define deficits or changes that may occur in ad patients compared with control group. thirteen ad patients and 13 age- and education-matched normal controls were tested in two visual search tasks (one was a conjunction task, where feature binding is required. the other was a subset task, where group stimuli is needed without feature binding) using fmri techniques. after stereotactical normalization, voxel-by-voxel t statistics was used to compare activated brain areas between patients and control subjects. our findings suggest that both search tasks are controlled by partially overlapping cerebral networks, including parietal, frontal and occipital-temporal cortical regions and primary visual cortex. the ad patient group showed less activation in both parietal lobes and the left frontal regions, while increased activation was found in the right frontal lobes and the right occipito-temporal cortical regions with the conjunction task. in the subset task, decreased activation in ad patients was seen in the left parietal lobe and bilateral frontal lobes, while increased activation was seen in both medial temporal lobes. in addition, for the comparison between tasks, the difference is very small for ad patients. control group showed a higher amplitude in the fight prefrontal region, temporal cortical regions and parietal lobe. these results indicate that attention deficits in ad patients may be attributed to both binding problem and grouping inefficiency. (c) 2005 elsevier ireland ltd. all rights reserved.
WOS关键词	SUPERIOR PARIETAL CORTEX ; SELECTIVE ATTENTION ; CONJUNCTION SEARCH ; DIVIDED ATTENTION ; SPATIAL ATTENTION ; DYSFUNCTION ; IMPAIRMENT ; ACTIVATION ; PATTERNS ; TASK
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
语种	英语
出版者	ELSEVIER IRELAND LTD
WOS记录号	WOS:000230745800004
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2175805
专题	高能物理研究所
通讯作者	Li, KC
作者单位	1.Capital Univ Med Sci, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China 2.Chinese Acad Sci, Inst High Energy Phys, Beijing 100039, Peoples R China 3.Peking Univ, Dept Psychol, Beijing 100034, Peoples R China
推荐引用方式 GB/T 7714	Hao, J,Li, KC,Li, K,et al. Visual attention deficits in alzheimer's disease: an fmri study[J]. Neuroscience letters,2005,385(1):18-23.
APA	Hao, J.,Li, KC.,Li, K.,Zhang, DX.,Wang, W.,...&Zhou, XL.(2005).Visual attention deficits in alzheimer's disease: an fmri study.Neuroscience letters,385(1),18-23.
MLA	Hao, J,et al."Visual attention deficits in alzheimer's disease: an fmri study".Neuroscience letters 385.1(2005):18-23.

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