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	The antihyperlipidemic effects of fullerenol nanoparticles via adjusting the gut microbiota in vivo
	Li,Juan1; Lei,Runhong1; Li,Xin2; Xiong,Fengxia1; Zhang,Quanyang2; Zhou,Yue2; Yang,Shengmei1; Chang,Yanan1; Chen,Kui1; Gu,Weihong1
刊名	Particle and fibre toxicology
	2018-01-17
卷号	15期号:1
关键词	Fullerenols Gut microbiota Short-chain fatty acid (scfa) Blood lipids Butyrate-producing bacteria
ISSN号	1743-8977
DOI	10.1186/s12989-018-0241-9
通讯作者	Wu,chongming(cmwu@implad.ac.cn) ; Xing,gengmei(xinggm@ihep.ac.cn)
英文摘要	Abstractbackgroundnanoparticles (nps) administered orally will meet the gut microbiota, but their impacts on microbiota homeostasis and the consequent physiological relevance remain largely unknown. here, we describe the modulatory effects and the consequent pharmacological outputs of two orally administered fullerenols nps (fol1 c60(oh)7(o)8 and fol113 c60(oh)11(o)6) on gut microbiota.resultsadministration of fol1 and fol113 nps for 4?weeks largely shifted the overall structure of gut microbiota in mice. the bacteria belonging to putative short-chain fatty acids (scfas)-producing genera were markedly increased by both nps, especially fol1. dynamic analysis showed that major scfas-producers and key butyrate-producing gene were significantly enriched after treatment for 7–28?days. the fecal contents of scfas were consequently increased, which was accompanied by significant decreases of triglycerides and total cholesterol levels in the blood and liver, with fol1 superior to fol113. under cultivation in vitro, fullerenols nps can be degraded by gut flora and exhibited a similar capacity of inulin to promote scfa-producing genera. the differential effects of fol1 and fol113 nps on the microbiome may be attributable to their subtly varied surface structures.conclusionsthe two fullerenol nps remarkably modulate the gut microbiota and selectively enrich scfa-producing bacteria, which may be an important reason for their anti-hyperlipidemic effect in mice.
语种	英语
出版者	BioMed Central
WOS记录号	BMC:10.1186/S12989-018-0241-9
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2175670
专题	高能物理研究所
通讯作者	Wu,Chongming; Xing,Gengmei
作者单位	1. 2.Pharmacology and Toxicology Research Center, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College
推荐引用方式 GB/T 7714	Li,Juan,Lei,Runhong,Li,Xin,et al. The antihyperlipidemic effects of fullerenol nanoparticles via adjusting the gut microbiota in vivo[J]. Particle and fibre toxicology,2018,15(1).
APA	Li,Juan.,Lei,Runhong.,Li,Xin.,Xiong,Fengxia.,Zhang,Quanyang.,...&Xing,Gengmei.(2018).The antihyperlipidemic effects of fullerenol nanoparticles via adjusting the gut microbiota in vivo.Particle and fibre toxicology,15(1).
MLA	Li,Juan,et al."The antihyperlipidemic effects of fullerenol nanoparticles via adjusting the gut microbiota in vivo".Particle and fibre toxicology 15.1(2018).

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