| The pneumotoxic effect and indium ion release induced by indium tin oxide nanoparticles | |
| Ghent, Zhaofang1,2; Li, Jinxia2; Chen, Linlin2,3; Zhao, Feng2; Jiang, Juncheng1 | |
| 刊名 | Journal of nanoscience and nanotechnology
 |
| 2019-08-01 | |
| 卷号 | 19期号:8页码:4357-4365 |
| 关键词 | Indium tin oxide nanoparticles (ito nps) Pneumotoxic effect Indium ion release |
| ISSN号 | 1533-4880 |
| DOI | 10.1166/jnn.2019.16924 |
| 通讯作者 | Zhao, feng() ; Jiang, juncheng() |
| 英文摘要 | With the increasing industrial production and the broaden applications of indium tin oxide (ito) materials, frequent exposure has posed great concerns for people, especially the workers in the indium related manufacturing plants. the exposed-workers have been reported to adverse effect and even die from the ito-induced pulmonary disorders called "indium lung" in addition to the epidemiologic studies, the increasing animal studies also demonstrated the lung injuries induced by the acute or chronic respiratory exposure of ito nanoparticles (ito nps). they could enter into the cells owing to the small particle size and induce oxidative stress, inflammatory responses, cytotoxicity or even genotoxicity. the indium ions released from the ito particles via lysosomal acidification considered as the actual entity responsible for the toxicity of ito nps. to date, no effective therapies are available against ito-induced pulmonary diseases, which calls for the full explorations of the pathological factors. our present mini-review summarizes the current reports on ito nanoparticles-induced pneumotoxic effect with focus on the indium ion release, which could help warrant the health risks of ito and other ito-based materials. |
| 资助项目 | National Natural Science Foundation of China[21301176] ; National Natural Science Foundation of China[11305182] |
| WOS关键词 | PULMONARY ALVEOLAR PROTEINOSIS ; INTRATRACHEAL INSTILLATIONS ; OXIDATIVE STRESS ; ITO PRODUCTION ; LUNG INJURY ; PARTICLES ; TOXICITY ; EXPOSURE ; WORKERS ; CYTOTOXICITY |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 语种 | 英语 |
| 出版者 | AMER SCIENTIFIC PUBLISHERS |
| WOS记录号 | WOS:000462338300001 |
| 资助机构 | National Natural Science Foundation of China |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2160637 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Zhao, Feng; Jiang, Juncheng |
| 作者单位 | 1.Nanjing Tech Univ, Coll Safety Sci & Engn, Nanjing 211816, Jiangsu, Peoples R China 2.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China 3.Shanxi Med Univ, Coll Pharm, Taiyuan 030001, Shanxi, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ghent, Zhaofang,Li, Jinxia,Chen, Linlin,et al. The pneumotoxic effect and indium ion release induced by indium tin oxide nanoparticles[J]. Journal of nanoscience and nanotechnology,2019,19(8):4357-4365. |
| APA | Ghent, Zhaofang,Li, Jinxia,Chen, Linlin,Zhao, Feng,&Jiang, Juncheng.(2019).The pneumotoxic effect and indium ion release induced by indium tin oxide nanoparticles.Journal of nanoscience and nanotechnology,19(8),4357-4365. |
| MLA | Ghent, Zhaofang,et al."The pneumotoxic effect and indium ion release induced by indium tin oxide nanoparticles".Journal of nanoscience and nanotechnology 19.8(2019):4357-4365. |
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