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	Gd-metallofullerenol nanoparticles cause intracellular accumulation of pdgfr-alpha and morphology alteration of fibroblasts
	Tang, Jinglong1,2,5; Guo, Mengyu1,2,6; Wang, Peng3,4; Liu, Jing1,2; Xiao, Yating1,2,6; Cheng, Wenting5; Gao, Jinling5; Hu, Wenquan3,4; Miao, Qing Robert1,2,3,4
刊名	Nanoscale
	2019-03-21
卷号	11期号:11页码:4743-4750
ISSN号	2040-3364
DOI	10.1039/c8nr08667b
通讯作者	Miao, qing robert(miaoq@nanoctr.cn)
英文摘要	Gadolinium-metallofullerenols (gd@c-82(oh)(22)) are a promising agent for cancer therapy and have shown beneficial effects in regulating the tumor microenvironment with low toxicity. however, the underlying mechanism by which gd@c-82(oh)(22) interacts with fibroblasts remains unclear. in order to explore the critical role that activated fibroblasts play in tumorigenesis and fibrosis, we investigated the regulatory effect of gd@c-82(oh)(22) in fibroblast activation and oncogenic transformation, and found that the pdgfr-alpha is an essential molecule in modulating the morphology and functional changes in fibroblasts after gd@c-82(oh)(22) treatment. apart from increasing the pdgfr-alpha protein level, gd@c-82(oh)(22) nanoparticles also significantly increased the protein level of rab5, which is required for regulating pdgfr-alpha endosomal recycling. the rab5-mediated recycling of pdgfr-alpha maybe attributed to the gd@c-82(oh)(22) regulated inhibition of fibroblast activation. overall, our work demonstrated that gd@c-82(oh)(22)( )nanoparticles can attenuate the pdgf-stimulated phosphorylation of pdgfr-alpha in fibroblasts and suppress the fibroblast activation by interrupting endosomal recycling. these findings may be contributed to the collagen accumulation for encaging cancer.
资助项目	National Natural Science Foundation of China[31571027] ; National Natural Science Foundation of China[81872651] ; Ministry of Science and Technology of China (National Basic Research Program)[2016YFA0201600] ; Division of Pediatric Surgery, Medical College of Wisconsin (MCW) ; Division of Pediatric Pathology, Medical College of Wisconsin (MCW) ; Advancing a Healthier Wisconsin endowment ; Children's Hospital of Wisconsin Research Institute Pilot Innovative Research Grant
WOS关键词	PANCREATIC-CANCER METASTASIS ; GROWTH-FACTOR PDGF ; RECEPTOR-ALPHA ; STEM-CELLS ; BETA ; INHIBIT
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000462669600049
资助机构	National Natural Science Foundation of China ; Ministry of Science and Technology of China (National Basic Research Program) ; Division of Pediatric Surgery, Medical College of Wisconsin (MCW) ; Division of Pediatric Pathology, Medical College of Wisconsin (MCW) ; Advancing a Healthier Wisconsin endowment ; Children's Hospital of Wisconsin Research Institute Pilot Innovative Research Grant
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2160633
专题	高能物理研究所
通讯作者	Miao, Qing Robert
作者单位	1.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China 3.Med Coll Wisconsin, Dept Surg, Childrens Res Inst, 8700 W Wisconsin Ave, Milwaukee, WI 53226 USA 4.Med Coll Wisconsin, Dept Pathol, Childrens Res Inst, Milwaukee, WI 53226 USA 5.Qingdao Univ, Sch Publ Hlth, Qingdao 226021, Shandong, Peoples R China 6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Tang, Jinglong,Guo, Mengyu,Wang, Peng,et al. Gd-metallofullerenol nanoparticles cause intracellular accumulation of pdgfr-alpha and morphology alteration of fibroblasts[J]. Nanoscale,2019,11(11):4743-4750.
APA	Tang, Jinglong.,Guo, Mengyu.,Wang, Peng.,Liu, Jing.,Xiao, Yating.,...&Miao, Qing Robert.(2019).Gd-metallofullerenol nanoparticles cause intracellular accumulation of pdgfr-alpha and morphology alteration of fibroblasts.Nanoscale,11(11),4743-4750.
MLA	Tang, Jinglong,et al."Gd-metallofullerenol nanoparticles cause intracellular accumulation of pdgfr-alpha and morphology alteration of fibroblasts".Nanoscale 11.11(2019):4743-4750.

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