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	Peptide self-assembly nanoparticles loaded with panobinostat to activate latent human immunodeficiency virus
	Kuai, Qiyuan1; Wang, Yu1; Gao, Fenghua1; Qi, Yingqiu2,3; Wang, Rui4; Wang, Yanbing1,5; Lu, Xiaofan4; Zhao, Ying2,6; Nie, Guangjun2,6; He, Min1
刊名	Journal of biomedical nanotechnology
	2019-05-01
卷号	15期号:5页码:979-992
关键词	Hiv reservoir Latent hiv Histone deacetylase inhibitors Panobinostat Peptide self-assembly Nanoparticles
ISSN号	1550-7033
DOI	10.1166/jbn.2019.2764
通讯作者	Jiang, xingwei(13910216274@163.com) ; Ren, suping(rensp12@yahoo.com) ; Yu, qun(yuqun1970@outlook.com)
英文摘要	Highly active antiretroviral therapy (haart) can turn human immunodeficiency virus-1 (hiv-1) infection into a controllable chronic disease, but because of the presence of an hiv reservoir, it cannot completely eliminate the virus in hiv-infected patients. the activation of latent reservoirs is the key to the successful treatment of acquired immune deficiency syndrome (aids). as a class of latency-reversing agents (lras), histone deacetylase inhibitors (hdacis), such as panobinostat, have been the most widely investigated, but most of them have resulted in only a modest and transient activation of hiv latency. to improve the potency of latency activation, an injectable peptide self-assembly nanoparticle loaded with panobinostat (pnp-p) was designed with the ability to efficiently penetrate the cell to achieve better drug delivery and activation of latent hiv. the results confirmed that these nanoparticles could activate latently infected cells in vitro and in vivo and activate peripheral blood mononuclear cells (pbmcs) from latently infected patients ex vivo. increased cellular drug uptake made the pnp-p more effective than panobinostat alone. therefore, this strategy demonstrates that nanotechnology can help improve the activation of latent hiv, and this study lays a foundation for further development of lra delivery systems for use against an hiv reservoir.
资助项目	National Key R&D Program of China[2017YFSF110080] ; Program for the 13th Five-year Plan of China[2017ZX10202101004] ; National Science and Technology Major Project of China[2018ZX09J18111] ; Beijing key lab for HIV/AIDS research[BZ0089]
WOS关键词	HISTONE DEACETYLASE INHIBITOR ; CD4(+) T-CELLS ; HIV-1 LATENCY ; ANTIRETROVIRAL THERAPY ; REVERSING AGENTS ; INFECTED-CELLS ; REACTIVATION ; CHOLESTEROL ; RESERVOIRS ; ARGININE
WOS研究方向	Science & Technology - Other Topics ; Materials Science
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Biomaterials
语种	英语
出版者	AMER SCIENTIFIC PUBLISHERS
WOS记录号	WOS:000461761600010
资助机构	National Key R&D Program of China ; Program for the 13th Five-year Plan of China ; National Science and Technology Major Project of China ; Beijing key lab for HIV/AIDS research
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2160513
专题	高能物理研究所
通讯作者	Jiang, Xingwei; Ren, Suping; Yu, Qun
作者单位	1.Beijing Inst Transfus Med, Beijing 100850, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 3.Zhengzhou Univ, Sch Basic Med Sci, Zhengzhou 450001, Henan, Peoples R China 4.Capital Med Univ, Beijing Youan Hosp, Beijing Key Lab HIV AIDS Res, Beijing 100069, Peoples R China 5.Jilin Univ, Sch Life Sci, Changchun 130012, Jilin, Peoples R China 6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 7.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Beijing 100083, Peoples R China
推荐引用方式 GB/T 7714	Kuai, Qiyuan,Wang, Yu,Gao, Fenghua,et al. Peptide self-assembly nanoparticles loaded with panobinostat to activate latent human immunodeficiency virus[J]. Journal of biomedical nanotechnology,2019,15(5):979-992.
APA	Kuai, Qiyuan.,Wang, Yu.,Gao, Fenghua.,Qi, Yingqiu.,Wang, Rui.,...&Yu, Qun.(2019).Peptide self-assembly nanoparticles loaded with panobinostat to activate latent human immunodeficiency virus.Journal of biomedical nanotechnology,15(5),979-992.
MLA	Kuai, Qiyuan,et al."Peptide self-assembly nanoparticles loaded with panobinostat to activate latent human immunodeficiency virus".Journal of biomedical nanotechnology 15.5(2019):979-992.

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