Integration mechanisms of transgenes and population fitness of GH transgenic fish

CORC > 水生生物研究所 > 鱼类生物学及渔业生物技术研究中心 > 期刊论文

	Integration mechanisms of transgenes and population fitness of GH transgenic fish
	Hu Wei; Zhu ZuoYan
刊名	SCIENCE CHINA-LIFE SCIENCES
	2010-04-01
卷号	53 期号:4 页码:401-408
关键词	transgene integration mechanism GH transgenic fish population fitness
ISSN号	1674-7305
通讯作者	Zhu, ZY, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
中文摘要	It has been more than 20 years since the first batch of transgenic fish was produced. Five stable germ-line transmitted growth hormone (GH) transgenic fish lines have been generated. This paper reviews the mechanisms of integration and gene targeting of the transgene, as well as the viability, reproduction and transgenic approaches for the reproductive containment of GH-transgenic fish. Further, we propose that it should be necessary to do the following studies, in particularly, of the breeding of transgenic fish: to assess the fitness of transgenic fish in an aqueous environment with a large space and a complex structure; and to develop a controllable on-off strategy of reproduction in transgenic fish.
英文摘要	It has been more than 20 years since the first batch of transgenic fish was produced. Five stable germ-line transmitted growth hormone (GH) transgenic fish lines have been generated. This paper reviews the mechanisms of integration and gene targeting of the transgene, as well as the viability, reproduction and transgenic approaches for the reproductive containment of GH-transgenic fish. Further, we propose that it should be necessary to do the following studies, in particularly, of the breeding of transgenic fish: to assess the fitness of transgenic fish in an aqueous environment with a large space and a complex structure; and to develop a controllable on-off strategy of reproduction in transgenic fish.
学科主题	Biology
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Biology
研究领域[WOS]	Life Sciences & Biomedicine - Other Topics
关键词[WOS]	CARP CYPRINUS-CARPIO ; GROWTH-HORMONE GENE ; GONADOTROPIN-RELEASING-HORMONE ; SALMON ONCORHYNCHUS-KISUTCH ; ZINC-FINGER NUCLEASES ; COHO SALMON ; RAINBOW-TROUT ; ATLANTIC SALMON ; GERM-LINE ; SWIMMING PERFORMANCE
收录类别	SCI
资助信息	Development Plan of the State Key Fundamental Research of China [2007CB109205, 2007CB109206]; National Natural Science Foundation of China [30930069]
语种	英语
WOS记录号	WOS:000277417800002
公开日期	2010-12-23
内容类型	期刊论文
源URL	[http://ir.ihb.ac.cn/handle/342005/13621]
专题	水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文
作者单位	Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
推荐引用方式 GB/T 7714	Hu Wei,Zhu ZuoYan. Integration mechanisms of transgenes and population fitness of GH transgenic fish[J]. SCIENCE CHINA-LIFE SCIENCES,2010,53(4):401-408.
APA	Hu Wei,&Zhu ZuoYan.(2010).Integration mechanisms of transgenes and population fitness of GH transgenic fish.SCIENCE CHINA-LIFE SCIENCES,53(4),401-408.
MLA	Hu Wei,et al."Integration mechanisms of transgenes and population fitness of GH transgenic fish".SCIENCE CHINA-LIFE SCIENCES 53.4(2010):401-408.