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Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as selective Btk inhibitors with improved pharmacokinetic properties for the treatment of rheumatoid arthritis
Linhong He; Heying Pei; Chufeng Zhang; Mingfeng Shao; Dan Li; Mingli Tang; Taijing Wang; Xiaoxin Chen; Mingli Xiang; Lijuan Chen
刊名EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
2018
卷号Vol.145页码:96-112
关键词Btk Inhibitor Selectivity Bioavailability Aqueous solubility Rheumatoid arthritis
ISSN号0223-5234
URL标识查看原文
内容类型期刊论文
URI标识http://www.corc.org.cn/handle/1471x/1832827
专题四川大学
作者单位b Guangdong Zhongsheng Pharmaceutical Co., Ltd., Dongguan, Guangdong 523325, China a State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan 610041, PR China
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GB/T 7714
Linhong He,Heying Pei,Chufeng Zhang,et al. Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as selective Btk inhibitors with improved pharmacokinetic properties for the treatment of rheumatoid arthritis[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2018,Vol.145:96-112.
APA Linhong He.,Heying Pei.,Chufeng Zhang.,Mingfeng Shao.,Dan Li.,...&Lijuan Chen.(2018).Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as selective Btk inhibitors with improved pharmacokinetic properties for the treatment of rheumatoid arthritis.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,Vol.145,96-112.
MLA Linhong He,et al."Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as selective Btk inhibitors with improved pharmacokinetic properties for the treatment of rheumatoid arthritis".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY Vol.145(2018):96-112.
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