Dietary Bile Salt Types Influence the Composition of Biliary Bile Acids and Gut Microbiota in Grass Carp

doi:10.3389/fmicb.2018.02209

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	Dietary Bile Salt Types Influence the Composition of Biliary Bile Acids and Gut Microbiota in Grass Carp
	Wang, Gui-Tang 2,3,4; Li, Ming 2,3,4; Zou, Hong 3,4; Li, Wen-Xiang 2,3,4; Jakovlic, Ivan 1; Zhang, Jing 2; Wu, Shan-Gong 2,3,4; Xiong, Fan 2,3,4
刊名	FRONTIERS IN MICROBIOLOGY
	2018-09-18
卷号	9 页码:13
关键词	bile acid gut microbiota lipid metabolism freshwater fish in vivo
ISSN号	1664-302X
DOI	10.3389/fmicb.2018.02209
英文摘要	Lipid metabolism can influence host's health. There is increasing evidence for interplay between two key regulating factors in lipid metabolism: bile acids (BAs) and gut microbiota. However, very little is known about how types of different diet-supplemented bile salts (BS) influence this interaction in vivo. We sought to explore these relationships using grass carp (Ctenopharyngodon idellus), which often suffers functional disorder of liver and gallbladder. We studied fluctuations of BAs in the gall and changes of microbial communities in the gut in response to seven different diets: five different BS, chelating BS agent, and control. The BS comprised two primary BS [sodium taurochololate (TCAS) and sodium taurochenodeoxycholate (TCDCAS)], sodium tauroursodeoxycholate (TUDCAS), and two secondary BS [sodium taurodeoxycholate (TDCAS) and sodium taurolithocholate (TLCAS)]. Supplementation of primary BS caused a more significant fluctuation of biliary BAs than secondary BS, and TCAS caused a more prominent increase than TCDCAS and TUDCAS. For the gut microbiota, primary BS tended to increase their diversity and induce community succession, secondary BS resulted in a higher firmicutes/bacteroidetes ratio, while TUDCAS had no significant effects. Changes of the gut microbiota triggered by different types of BS caused alteration in BAs biotransformation. Two-obesity-associated families, Lachnospiraceae and Ruminococcaceae were positively correlated with biliary cholic acid (CA), taurochenodeoxycholic acid (TCDCA), and deoxycholic acid (DCA). As both primary and secondary BS resulted in increased synthesis of toxic secondary Bas by the gut microbiota, future studies should pay closer attention to gut microbiota when considering BA treatment.
资助项目	National Natural Science Foundation of China[31872612] ; earmarked fund for China Agriculture Research System[CARS-45-15]
WOS研究方向	Microbiology
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000444816100001
内容类型	期刊论文
源URL	[http://202.127.146.157/handle/2RYDP1HH/5762]
专题	中国科学院武汉植物园
通讯作者	Wang, Gui-Tang; Wu, Shan-Gong
作者单位	1.Wuhan Inst Biotechnol, Biotransduct Lab, Wuhan, Hubei, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan, Hubei, Peoples R China 4.Chinese Acad Sci, Key Lab Aquaculture Dis Control, Minist Agr, Inst Hydrobiol, Wuhan, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Wang, Gui-Tang,Li, Ming,Zou, Hong,et al. Dietary Bile Salt Types Influence the Composition of Biliary Bile Acids and Gut Microbiota in Grass Carp[J]. FRONTIERS IN MICROBIOLOGY,2018,9:13.
APA	Wang, Gui-Tang.,Li, Ming.,Zou, Hong.,Li, Wen-Xiang.,Jakovlic, Ivan.,...&Xiong, Fan.(2018).Dietary Bile Salt Types Influence the Composition of Biliary Bile Acids and Gut Microbiota in Grass Carp.FRONTIERS IN MICROBIOLOGY,9,13.
MLA	Wang, Gui-Tang,et al."Dietary Bile Salt Types Influence the Composition of Biliary Bile Acids and Gut Microbiota in Grass Carp".FRONTIERS IN MICROBIOLOGY 9(2018):13.