Integrative Transcriptomic and microRNAomic Profiling Reveals Immune Mechanism for the Resilience to Soybean Meal Stress in Fish Gut and Liver | |
Zhang, Yong-An3,4,5; Chen, Dan-Dan3,4,5; Wang, Zhao-Xi2,5; Li, Xian-Mei2,5; Xu, Xuan1; Cheng, Ying-Yin5; Zhang, Xiang-Yang2,5; Cui, Zheng-Wei2,5; Wang, Biao5; Wu, Nan3,4,5 | |
刊名 | FRONTIERS IN PHYSIOLOGY |
2018-09-10 | |
卷号 | 9页码:20 |
关键词 | soybean meal induced enteritis resilience transcriptome miRNAome gut-liver immunity grass carp |
ISSN号 | 1664-042X |
DOI | 10.3389/fphys.2018.01154 |
英文摘要 | In aquafeeds, fish-meal has been commonly replaced with plant protein, which often causes enteritis. Currently, foodborne enteritis has few solutions in regards to prevention or cures. The recovery mechanism from enteritis in herbivorous fish may further help understand prevention or therapy. However, few reports could be found regarding the recovery or resilience to fish foodborne enteritis. In this study, grass carp was used as an animal model for soybean meal induced enteritis and it was found that the fish could adapt to the soybeanmeal at a moderate level of substitution. Resilience to soybeanmeal stress was found in the 40% soybean meal group for juvenile fish at growth performance, morphological and gene expression levels, after a 7-week feeding trial. Furthermore, the intestinal transcriptomic data, including transcriptome and miRNAome, was applied to demonstrate resilience mechanisms. The result of this study revealed that in juvenile grass carp after a 7-week feeding cycle with 40% soybean meal, the intestine recovered via enhancing both an immune tolerance and wound healing, the liver gradually adapted via re-balancing immune responses, such as phagosome and complement cascades. Also, many immune factors in the gut and liver were systemically revealed among stages of on-setting, remising, and recovering (or relief). In addition, miRNA regulation played a key role in switching immune states. Thus, the present data systemically demonstrated that the molecular adaptation mechanism of fish gut-liver immunity is involved in the resilience to soybean meal stress. |
资助项目 | National Basic Research Program of China[2014CB138601] ; National Natural Science Foundation of China[31472307] ; Knowledge Innovation Program of the Chinese Academy of Sciences |
WOS研究方向 | Physiology |
语种 | 英语 |
出版者 | FRONTIERS MEDIA SA |
WOS记录号 | WOS:000444152800001 |
内容类型 | 期刊论文 |
源URL | [http://202.127.146.157/handle/2RYDP1HH/5702] |
专题 | 中国科学院武汉植物园 |
通讯作者 | Zhang, Yong-An |
作者单位 | 1.Huazhong Agr Univ, Coll Informat, Hubei Key Lab Agr Bioinformat, Wuhan, Hubei, Peoples R China 2.Univ Chinese Acad Sci, Coll Modern Agr Sci, Beijing, Peoples R China 3.Minist Agr, Key Lab Aquaculture Dis Control, Wuhan, Hubei, Peoples R China 4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 5.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Hubei, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Yong-An,Chen, Dan-Dan,Wang, Zhao-Xi,et al. Integrative Transcriptomic and microRNAomic Profiling Reveals Immune Mechanism for the Resilience to Soybean Meal Stress in Fish Gut and Liver[J]. FRONTIERS IN PHYSIOLOGY,2018,9:20. |
APA | Zhang, Yong-An.,Chen, Dan-Dan.,Wang, Zhao-Xi.,Li, Xian-Mei.,Xu, Xuan.,...&Wu, Nan.(2018).Integrative Transcriptomic and microRNAomic Profiling Reveals Immune Mechanism for the Resilience to Soybean Meal Stress in Fish Gut and Liver.FRONTIERS IN PHYSIOLOGY,9,20. |
MLA | Zhang, Yong-An,et al."Integrative Transcriptomic and microRNAomic Profiling Reveals Immune Mechanism for the Resilience to Soybean Meal Stress in Fish Gut and Liver".FRONTIERS IN PHYSIOLOGY 9(2018):20. |
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